EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    6.3.4.21 | Neuroblastoma |
19703994 |
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
1
1
4 |
| 6.3.4.21 | Neuroblastoma |
22570471 |
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 6.3.4.21 | nicotinate phosphoribosyltransferase deficiency |
19703994 |
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
1
1
4 |
| 6.3.4.21 | Ovarian Neoplasms |
28507103 |
Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
3
4 |
| 6.3.4.21 | Sarcoma |
19703994 |
The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
1
1
4 |
| 6.3.4.21 | Sarcoma |
22570471 |
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
