EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
    6.3.4.21 | Neoplasms |
22570471 |
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) activity by small molecule GMX1778 regulates reactive oxygen species (ROS)-mediated cytotoxicity in a p53- and nicotinic acid phosphoribosyltransferase1 (NAPRT1)-dependent manner. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 6.3.4.21 | Neoplasms |
24204194 |
Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
3
2
3
0 |
| 6.3.4.21 | Neoplasms |
24403854 |
Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
3
4
0 |
| 6.3.4.21 | Neoplasms |
25201160 |
NAMPT and NAPRT1: novel polymorphisms and distribution of variants between normal tissues and tumor samples. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
4
3
4
2 |
| 6.3.4.21 | Neoplasms |
26675378 |
Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors. |
causal interaction
ongoing research
unassigned |
2
4
0 |
| 6.3.4.21 | Neoplasms |
27390344 |
Dual and Specific Inhibition of NAMPT and PAK4 By KPT-9274 Decreases Kidney Cancer Growth. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
1
2
0 |
| 6.3.4.21 | Neoplasms |
28507103 |
Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility to NAMPT Inhibitors, and DNA Repair. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
3
3
4 |
| 6.3.4.21 | Neoplasms |
32098966 |
The complex genetic landscape of familial MDS and AML reveals pathogenic germline variants. |
unassigned |
0 |
| 6.3.4.21 | Neoplasms |
34187548 |
Anti-tumor NAMPT inhibitor, KPT-9274, mediates gender-dependent murine anemia and nephrotoxicity by regulating SIRT3-mediated SOD deacetylation. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
| 6.3.4.21 | Neoplasms |
34200964 |
Targeting the NAD Salvage Synthesis Pathway as a Novel Therapeutic Strategy for Osteosarcomas with Low NAPRT Expression. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
1
4
0 |
