EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   6.2.1.64 | Carcinoma |
26592553 |
MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma. |
ongoing research
unassigned |
4
0 |
| 6.2.1.64 | Carcinoma |
26807316 |
MLN4924, a Novel NEDD8-activating enzyme inhibitor, exhibits antitumor activity and enhances cisplatin-induced cytotoxicity in human cervical carcinoma: in vitro and in vivo study. |
causal interaction
ongoing research
therapeutic application
unassigned |
1
4
4
0 |
| 6.2.1.64 | Carcinoma |
29434977 |
Neddylation inhibitor MLN4924 induces G |
ongoing research
therapeutic application
unassigned |
1
1
0 |
| 6.2.1.64 | Carcinoma |
30341788 |
The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
3
3
2 |
| 6.2.1.64 | Carcinoma |
31880252 |
Design, synthesis and biological evaluation of 4-amino substituted 2H-chromen-2-one derivatives as an NEDD8 activating enzyme inhibitor in pancreatic cancer cells. |
causal interaction
therapeutic application
unassigned |
2
3
0 |
| 6.2.1.64 | Carcinoma, Squamous Cell |
30341788 |
The Nedd8-activating enzyme inhibitor MLN4924 (TAK-924/Pevonedistat) induces apoptosis via c-Myc-Noxa axis in head and neck squamous cell carcinoma. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
1
3
3
2 |
| 6.2.1.64 | Cholangiocarcinoma |
25229838 |
Neddylation pathway is up-regulated in human intrahepatic cholangiocarcinoma and serves as a potential therapeutic target. |
therapeutic application
unassigned |
4
0 |
| 6.2.1.64 | Colonic Neoplasms |
30402022 |
The Nedd8-activating enzyme inhibitor MLN4924 suppresses colon cancer cell growth via triggering autophagy. |
therapeutic application
unassigned |
3
0 |
| 6.2.1.64 | Colorectal Neoplasms |
26082455 |
Radiosensitization of Human Colorectal Cancer Cells by MLN4924: An Inhibitor of NEDD8-Activating Enzyme. |
ongoing research
therapeutic application
unassigned |
3
1
0 |
| 6.2.1.64 | Down Syndrome |
17611268 |
Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis. |
causal interaction
ongoing research
unassigned |
2
2
0 |
