EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category |
Confidence Level |
|---|
   1.14.11.67 | Breast Neoplasms |
15201984 |
A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo. |
ongoing research
unassigned |
2
0 |
| 1.14.11.67 | Breast Neoplasms |
17363312 |
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. |
causal interaction
therapeutic application
unassigned |
1
1
0 |
| 1.14.11.67 | Breast Neoplasms |
21105039 |
T cells reactive with HLA-A*0201 peptides from the histone demethylase JARID1B are found in the circulation of breast cancer patients. |
diagnostic usage
ongoing research
therapeutic application
unassigned |
3
3
1
0 |
| 1.14.11.67 | Breast Neoplasms |
21369698 |
PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
4
2
0 |
| 1.14.11.67 | Breast Neoplasms |
21821892 |
Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B. |
causal interaction
unassigned |
4
0 |
| 1.14.11.67 | Breast Neoplasms |
21937684 |
Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
3
1
0 |
| 1.14.11.67 | Breast Neoplasms |
22937203 |
Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
4
2
0 |
| 1.14.11.67 | Breast Neoplasms |
23408432 |
Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
4
2
4
0 |
| 1.14.11.67 | Breast Neoplasms |
23699411 |
Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes. |
therapeutic application
unassigned |
2
0 |
| 1.14.11.67 | Breast Neoplasms |
24412361 |
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. |
causal interaction
therapeutic application
unassigned |
3
1
0 |
