1.14.11.67 Adenocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29683067&form=6&db=m Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.14.11.67 Adenocarcinoma of Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34270886&form=6&db=m Histone demethylase KDM5A enhances cell proliferation, induces EMT in lung adenocarcinoma cells, and have a strong causal association with paclitaxel resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,2,4 1.14.11.67 African Swine Fever http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10760505&form=6&db=m An ARID family protein binds to the African swine fever virus encoded ubiquitin conjugating enzyme, UBCv1. unassigned - 1.14.11.67 Aortic Valve Stenosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18805276&form=6&db=m Induction by left ventricular overload and left ventricular failure of the human Jumonji gene (JARID2) encoding a protein that regulates transcription and reexpression of a protective fetal program. diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.11.67 Ataxia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34530748&form=6&db=m A novel de novo KDM5C variant in a female with global developmental delay and ataxia: a case report. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336460&form=6&db=m A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. causal interaction,ongoing research,unassigned 1,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237901&form=6&db=m PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen? causal interaction,ongoing research,unassigned 3,3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530026&form=6&db=m Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer. diagnostic usage,therapeutic application,unassigned 4,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12617814&form=6&db=m Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. causal interaction,unassigned 3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14516692&form=6&db=m Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. causal interaction,unassigned 3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15201984&form=6&db=m A short region of the promoter of the breast cancer associated PLU-1 gene can regulate transcription in vitro and in vivo. ongoing research,unassigned 2,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363312&form=6&db=m PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21105039&form=6&db=m T cells reactive with HLA-A*0201 peptides from the histone demethylase JARID1B are found in the circulation of breast cancer patients. diagnostic usage,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21369698&form=6&db=m PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21821892&form=6&db=m Crystallization and preliminary crystallographic analysis of a PHD domain of human JARID1B. causal interaction,unassigned 4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21937684&form=6&db=m Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22937203&form=6&db=m Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23408432&form=6&db=m Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23699411&form=6&db=m Unliganded progesterone receptor-mediated targeting of an RNA-containing repressive complex silences a subset of hormone-inducible genes. therapeutic application,unassigned 2,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24412361&form=6&db=m The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24802759&form=6&db=m Histone demethylase jumonji AT-rich interactive domain 1B (JARID1B) controls mammary gland development by regulating key developmental and lineage specification genes. causal interaction,therapeutic application,unassigned 3,3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24924415&form=6&db=m Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24937458&form=6&db=m JARID1B is a luminal lineage-driving oncogene in breast cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125737&form=6&db=m Immunohistochemical detection and clinicopathological significance of JARID1B/KDM5B and P16 expression in invasive ductal carcinoma of the breast. diagnostic usage,ongoing research,unassigned 1,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182878&form=6&db=m Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26621457&form=6&db=m MicroRNAs regulate KDM5 histone demethylases in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26645689&form=6&db=m Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. ongoing research,therapeutic application,unassigned 1,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26841866&form=6&db=m Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. causal interaction,therapeutic application,unassigned 3,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917489&form=6&db=m Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27102007&form=6&db=m Expression of ANRIL-Polycomb Complexes-CDKN2A/B/ARF Genes in Breast Tumors: Identification of a Two-Gene (EZH2/CBX7) Signature with Independent Prognostic Value. diagnostic usage,ongoing research,unassigned 1,3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27224921&form=6&db=m Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27270439&form=6&db=m Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282222&form=6&db=m A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30149757&form=6&db=m Genome-Wide Methylation Analysis Identifies NOX4 and KDM5A as Key Regulators in Inhibiting Breast Cancer Cell Proliferation by Ginsenoside Rg3. causal interaction,diagnostic usage,unassigned 3,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30472020&form=6&db=m KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30588710&form=6&db=m JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer. causal interaction,unassigned 1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30650517&form=6&db=m Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30978340&form=6&db=m KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31060229&form=6&db=m Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B. ongoing research,therapeutic application,unassigned 4,3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776402&form=6&db=m Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805991&form=6&db=m Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31949850&form=6&db=m JARID1B modulates breast cancer cell apoptosis by regulating p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985200&form=6&db=m Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32003509&form=6&db=m Long noncoding RNA RHPN1-AS1, induced by KDM5B, is involved in breast cancer via sponging miR-6884-5p. causal interaction,unassigned 4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33145271&form=6&db=m Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer. causal interaction,ongoing research,unassigned 4,3,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450359&form=6&db=m FBXL10 promotes ERR? protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERR?. causal interaction,ongoing research,unassigned 1,4,0 1.14.11.67 Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33977073&form=6&db=m The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Bronchiolitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33851876&form=6&db=m Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis. unassigned - 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226085&form=6&db=m Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20231316&form=6&db=m Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. unassigned - 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406991&form=6&db=m Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20863814&form=6&db=m Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21220025&form=6&db=m Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. causal interaction,unassigned 3,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788502&form=6&db=m Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. causal interaction,therapeutic application,unassigned 2,3,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23778974&form=6&db=m Outcome after surgery for primary hyperaldosteronism may depend on KCNJ5 tumor mutation status: a population-based study from Western Norway. diagnostic usage,ongoing research,unassigned 4,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24412361&form=6&db=m The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24481781&form=6&db=m Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein. ongoing research,therapeutic application,unassigned 4,2,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25596733&form=6&db=m SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25628922&form=6&db=m KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25956476&form=6&db=m Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26067852&form=6&db=m Marek's disease: Genetic regulation of gallid herpesvirus 2 infection and latency. causal interaction,unassigned 3,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26621457&form=6&db=m MicroRNAs regulate KDM5 histone demethylases in breast cancer cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050510&form=6&db=m H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27246838&form=6&db=m Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27874950&form=6&db=m miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28492139&form=6&db=m Histone Demethylase JARID1B is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression Via Demethylation of H3K27me3. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28706445&form=6&db=m Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30092824&form=6&db=m Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31125562&form=6&db=m Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31727771&form=6&db=m The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934196&form=6&db=m Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32868382&form=6&db=m KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33436536&form=6&db=m Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33450359&form=6&db=m FBXL10 promotes ERR? protein stability and proliferation of breast cancer cells by enhancing the mono-ubiquitylation of ERR?. causal interaction,ongoing research,unassigned 1,4,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33621431&form=6&db=m KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33977073&form=6&db=m The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinogenesis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276383&form=6&db=m Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530026&form=6&db=m Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer. diagnostic usage,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534467&form=6&db=m Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949125&form=6&db=m Loss of PBRM1 expression is associated with renal cell carcinoma progression. unassigned - 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23579952&form=6&db=m Connexin 26 is Down-Regulated by KDM5B in the Progression of Bladder Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23714058&form=6&db=m [Sonic hedgehog signaling enhanced the expression of histone demethylase, lysine-specific demethylase 8 in the head and neck squamous cell carcinoma cell line SCC-6]. causal interaction,ongoing research,unassigned 1,3,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24029645&form=6&db=m Radiogenomics of Clear Cell Renal Cell Carcinoma: Associations between CT Imaging Features and Mutations. ongoing research,unassigned 1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166983&form=6&db=m Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma. unassigned - 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663457&form=6&db=m Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26184998&form=6&db=m Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484545&form=6&db=m Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC). causal interaction,unassigned 4,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26551685&form=6&db=m Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27480251&form=6&db=m miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27584795&form=6&db=m Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28332632&form=6&db=m Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. unassigned - 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29290786&form=6&db=m KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507668&form=6&db=m Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030490&form=6&db=m Epigenetic modifiers: activities in renal cell carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30334004&form=6&db=m Genomic Alterations and Outcomes with VEGF-Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma. causal interaction,unassigned 4,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355483&form=6&db=m Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31221981&form=6&db=m The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31308693&form=6&db=m LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma. causal interaction,unassigned 2,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350278&form=6&db=m Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934196&form=6&db=m Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249685&form=6&db=m Genomic Landscape of Chinese Clear Cell Renal Cell Carcinoma Patients With Venous Tumor Thrombus Identifies Chromosome 9 and 14 Deletions and Related Immunosuppressive Microenvironment. diagnostic usage,unassigned 3,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34327974&form=6&db=m microRNA-486-5p functions as a tumor suppressor in gastric carcinoma via directly targeting KDM5B. unassigned - 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34391411&form=6&db=m Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 1.14.11.67 Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34522206&form=6&db=m Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Carcinoma, Ductal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530026&form=6&db=m Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer. diagnostic usage,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23922798&form=6&db=m Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909289&form=6&db=m JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26503415&form=6&db=m Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911146&form=6&db=m Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259236&form=6&db=m JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28566884&form=6&db=m Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. diagnostic usage,unassigned 3,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30344945&form=6&db=m Overexpression of KDM5B/JARID1B is associated with poor prognosis in hepatocellular carcinoma. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30353907&form=6&db=m Increased Expression of Lysine-Specific Demethylase 5B (KDM5B) Promotes Tumor Cell Growth in Hep3B Cells and is an Independent Prognostic Factor in Patients with Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985200&form=6&db=m Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32477467&form=6&db=m Correction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. causal interaction,unassigned 2,0 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33829656&form=6&db=m KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis. unassigned - 1.14.11.67 Carcinoma, Hepatocellular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34094675&form=6&db=m MiR-22 regulated T cell differentiation and hepatocellular carcinoma growth by directly targeting Jarid2. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.11.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162518&form=6&db=m Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25877751&form=6&db=m JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31562647&form=6&db=m Long non-coding RNA KDM5B anti-sense RNA 1 enhances tumor progression in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 2,3,0 1.14.11.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304897&form=6&db=m Overcoming of Radioresistance in Non-small Cell Lung Cancer by microRNA-320a Through HIF1?-Suppression Mediated Methylation of PTEN. ongoing research,unassigned 2,0 1.14.11.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34246759&form=6&db=m JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 1.14.11.67 Carcinoma, Non-Small-Cell Lung http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528900&form=6&db=m Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinoma, Ovarian Epithelial http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663457&form=6&db=m Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949125&form=6&db=m Loss of PBRM1 expression is associated with renal cell carcinoma progression. unassigned - 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24029645&form=6&db=m Radiogenomics of Clear Cell Renal Cell Carcinoma: Associations between CT Imaging Features and Mutations. ongoing research,unassigned 1,0 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24166983&form=6&db=m Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma. unassigned - 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484545&form=6&db=m Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC). causal interaction,unassigned 4,0 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26551685&form=6&db=m Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28332632&form=6&db=m Loss of chromosome Y leads to down regulation of KDM5D and KDM6C epigenetic modifiers in clear cell renal cell carcinoma. unassigned - 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030490&form=6&db=m Epigenetic modifiers: activities in renal cell carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30334004&form=6&db=m Genomic Alterations and Outcomes with VEGF-Targeted Therapy in Patients with Clear Cell Renal Cell Carcinoma. causal interaction,unassigned 4,0 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34391411&form=6&db=m Expression pattern and regulatory effect of lysine-specific demethylase 2A gene in clear cell renal cell carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 1.14.11.67 Carcinoma, Renal Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34522206&form=6&db=m Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23714058&form=6&db=m [Sonic hedgehog signaling enhanced the expression of histone demethylase, lysine-specific demethylase 8 in the head and neck squamous cell carcinoma cell line SCC-6]. causal interaction,ongoing research,unassigned 1,3,0 1.14.11.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29290786&form=6&db=m KDM5B overexpression predicts a poor prognosis in patients with squamous cell carcinoma of the head and neck. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.11.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355483&form=6&db=m Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.14.11.67 Carcinoma, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31221981&form=6&db=m The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32081420&form=6&db=m Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice. causal interaction,unassigned 1,0 1.14.11.67 Cardiomyopathy, Dilated http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30700554&form=6&db=m Myocardial-specific ablation of Jumonji and AT-rich interaction domain-containing 2 (Jarid2) leads to dilated cardiomyopathy in mice. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.14.11.67 CHARGE Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23920116&form=6&db=m Knockdown of fbxl10/kdm2bb rescues chd7 morphant phenotype in a zebrafish model of CHARGE syndrome. causal interaction,therapeutic application,unassigned 3,4,0 1.14.11.67 Cholangiocarcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714863&form=6&db=m KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Cleft Lip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20506229&form=6&db=m Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate. unassigned - 1.14.11.67 Cleft Lip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27328068&form=6&db=m Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts. ongoing research,therapeutic application,unassigned 2,1,0 1.14.11.67 Cleft Lip http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29374328&form=6&db=m Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate. therapeutic application,unassigned 1,0 1.14.11.67 Cleft Palate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20506229&form=6&db=m Expression and association data strongly support JARID2 involvement in nonsyndromic cleft lip with or without cleft palate. unassigned - 1.14.11.67 Cleft Palate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27328068&form=6&db=m Brazilian multicenter study of association between polymorphisms in CRISPLD2 and JARID2 and non-syndromic oral clefts. ongoing research,therapeutic application,unassigned 2,1,0 1.14.11.67 Cleft Palate http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29374328&form=6&db=m Possible effect of SNAIL family transcriptional repressor 1 polymorphisms in non-syndromic cleft lip with or without cleft palate. therapeutic application,unassigned 1,0 1.14.11.67 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28461115&form=6&db=m MiR-155 contributes to Th17 cells differentiation in dextran sulfate sodium (DSS)-induced colitis mice via Jarid2. ongoing research,unassigned 3,0 1.14.11.67 Colitis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30253332&form=6&db=m MiR-155 inhibition ameliorates 2, 4, 6-Trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis in rat via influencing the differentiation of Th17 cells by Jarid2. ongoing research,unassigned 2,0 1.14.11.67 Coloboma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21220025&form=6&db=m Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. causal interaction,unassigned 3,0 1.14.11.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25542019&form=6&db=m JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. ongoing research,unassigned 3,0 1.14.11.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939703&form=6&db=m JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257334&form=6&db=m KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 1.14.11.67 Colonic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33042830&form=6&db=m KDM5c Promotes Colon Cancer Cell Proliferation Through the FBXW7-c-Jun Regulatory Axis. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 1.14.11.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354547&form=6&db=m Depletion of JARID1B induces cellular senescence in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33109187&form=6&db=m JARID1B promotes colorectal cancer proliferation and Wnt/?-catenin signaling via decreasing CDX2 level. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 1.14.11.67 Colorectal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33160990&form=6&db=m Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/?-catenin pathway. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.14.11.67 Dehydration http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31038749&form=6&db=m Arabidopsis histone H3K4 demethylase JMJ17 functions in dehydration stress response. causal interaction,ongoing research,therapeutic application,unassigned 3,1,4,0 1.14.11.67 Diabetic Cardiomyopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30701683&form=6&db=m FBXL10 regulates cardiac dysfunction in diabetic cardiomyopathy via the PKC ?2 pathway. causal interaction,therapeutic application,unassigned 2,2,0 1.14.11.67 Diffuse Intrinsic Pontine Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31238504&form=6&db=m Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells. causal interaction,ongoing research,unassigned 3,2,0 1.14.11.67 Endometriosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33800594&form=6&db=m Peritoneal Modulators of EZH2-miR-155 Cross-Talk in Endometriosis. causal interaction,diagnostic usage,therapeutic application,unassigned 3,2,1,0 1.14.11.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23246292&form=6&db=m A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX. causal interaction,unassigned 3,0 1.14.11.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25652354&form=6&db=m Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability. causal interaction,unassigned 4,0 1.14.11.67 Epilepsy http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34210021&form=6&db=m Variable Phenotypes of Epilepsy, Intellectual Disability, and Schizophrenia Caused by 12p13.33-p13.32 Terminal Microdeletion in a Korean Family: A Case Report and Literature Review. unassigned - 1.14.11.67 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649241&form=6&db=m Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,3 1.14.11.67 Esophageal Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33230480&form=6&db=m MicroRNA let-7i Inhibits Histone Lysine Demethylase KDM5B to Halt Esophageal Cancer Progression. therapeutic application,unassigned 1,0 1.14.11.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534467&form=6&db=m Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27480251&form=6&db=m miR-194 inhibits proliferation and invasion and promotes apoptosis by targeting KDM5B in esophageal squamous cell carcinoma cells. causal interaction,ongoing research,therapeutic application,unassigned 3,3,3,0 1.14.11.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31308693&form=6&db=m LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma. causal interaction,unassigned 2,0 1.14.11.67 Esophageal Squamous Cell Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350278&form=6&db=m Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.14.11.67 Familial Primary Pulmonary Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351900&form=6&db=m Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. causal interaction,unassigned 3,0 1.14.11.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26566863&form=6&db=m The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma. therapeutic application,unassigned 2,0 1.14.11.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28432280&form=6&db=m Small molecules targeting histone demethylase genes (KDMs) inhibit growth of temozolomide-resistant glioblastoma cells. causal interaction,ongoing research,unassigned 3,3,0 1.14.11.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30951900&form=6&db=m Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1?-dependent pathway. causal interaction,ongoing research,unassigned 3,3,0 1.14.11.67 Glioblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31238504&form=6&db=m Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells. causal interaction,ongoing research,unassigned 3,2,0 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450384&form=6&db=m Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27246838&form=6&db=m Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27430402&form=6&db=m [Corrigendum] Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma. causal interaction,unassigned 4,0 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27641964&form=6&db=m Reduced expression of Jumonji, AT-rich interactive domain 2 (JARID2) in glioma inhibits tumor growth in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324315&form=6&db=m Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30728054&form=6&db=m SNHG1 promotes malignant biological behaviors of glioma cells via microRNA-154-5p/miR-376b-3p- FOXP2- KDM5B participating positive feedback loop. ongoing research,unassigned 2,0 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31238504&form=6&db=m Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells. causal interaction,ongoing research,unassigned 3,2,0 1.14.11.67 Glioma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34251962&form=6&db=m The function and mechanism of the JARID2/CCND1 axis in modulating glioma cell growth and sensitivity to temozolomide (TMZ). ongoing research,therapeutic application,unassigned 4,2,0 1.14.11.67 Head and Neck Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30080846&form=6&db=m KDM5 histone demethylases repress immune response via suppression of STING. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.11.67 Heart Defects, Congenital http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22194017&form=6&db=m Epigenetic mechanisms in cardiac development and disease. therapeutic application,unassigned 1,0 1.14.11.67 Heart Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29891551&form=6&db=m Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development. ongoing research,therapeutic application,unassigned 2,1,0 1.14.11.67 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20063376&form=6&db=m Identification of circulating placental mRNA in maternal blood of pregnancies affected with fetal congenital heart diseases at the second trimester of pregnancy: implications for early molecular screening. causal interaction,ongoing research,unassigned 2,3,0 1.14.11.67 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28665611&form=6&db=m Comprehensive Myocardial Proteogenomics Profiling Reveals C/EBP? as the Key Factor in the Lipid Storage of ARVC. ongoing research,unassigned 1,0 1.14.11.67 Heart Failure http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32618141&form=6&db=m DNA methylation patterns from peripheral blood separate coronary artery disease patients with and without heart failure. causal interaction,diagnostic usage,unassigned 3,3,0 1.14.11.67 Heart Septal Defects, Ventricular http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29891551&form=6&db=m Cardiac-specific developmental and epigenetic functions of Jarid2 during embryonic development. ongoing research,therapeutic application,unassigned 2,1,0 1.14.11.67 Hepatitis B http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28566884&form=6&db=m Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B. diagnostic usage,unassigned 3,0 1.14.11.67 Hirschsprung Disease http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34455465&form=6&db=m KDM5B promotes cell migration by regulating the noncanonical Wnt/PCP pathway in Hirschsprung's disease. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.11.67 Hyperglycemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19208907&form=6&db=m Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail. causal interaction,ongoing research,unassigned 1,3,0 1.14.11.67 Hyperglycinemia, Nonketotic http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799067&form=6&db=m Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics. causal interaction,unassigned 3,0 1.14.11.67 Hypersensitivity http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29997151&form=6&db=m Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 1.14.11.67 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26848384&form=6&db=m The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains. causal interaction,unassigned 1,0 1.14.11.67 Hypertension http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28351900&form=6&db=m Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function. causal interaction,unassigned 3,0 1.14.11.67 Hypertension, Pulmonary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30172777&form=6&db=m Histone demethylase JARID1B regulates proliferation and migration of pulmonary arterial smooth muscle cells in mice with chronic hypoxia-induced pulmonary hypertension via nuclear factor-kappa B (NFkB). causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.11.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24830456&form=6&db=m The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection. ongoing research,unassigned 3,0 1.14.11.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26083387&form=6&db=m RSV-Induced H3K4 Demethylase KDM5B Leads to Regulation of Dendritic Cell-Derived Innate Cytokines and Exacerbates Pathogenesis In Vivo. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947702&form=6&db=m Changes of host DNA methylation in domestic chickens infected with Salmonella enterica. diagnostic usage,therapeutic application,unassigned 1,1,0 1.14.11.67 Infections http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350278&form=6&db=m Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.14.11.67 Insulin Resistance http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31467927&form=6&db=m The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis. causal interaction,therapeutic application,unassigned 4,2,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16506132&form=6&db=m [Monogenic causes of X-linked mental retardation.] causal interaction,unassigned 4,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16538222&form=6&db=m A novel mutation in JARID1C gene associated with mental retardation. causal interaction,unassigned 4,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18596936&form=6&db=m Sex-specific expression of the X-linked histone demethylase gene Jarid1c in brain. causal interaction,unassigned 3,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18697827&form=6&db=m Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19320021&form=6&db=m Novel human pathological mutations. Gene symbol: JARID1C. Disease: mental retardation, X-linked. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19320022&form=6&db=m Novel human pathological mutations. Gene symbol: JARID1C. Disease: mental retardation, X-linked. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19320023&form=6&db=m Novel human pathological mutations. Gene symbol: JARID1C. Disease: mental retardation, X-linked. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19320024&form=6&db=m Novel human pathological mutations. Gene symbol: JARID1C. Disease: mental retardation, X-linked. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20067792&form=6&db=m Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233696&form=6&db=m [Progress on X-linked mental retardation related gene JARID1C.] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575681&form=6&db=m A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay. ongoing research,unassigned 2,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22326837&form=6&db=m A novel c.2T > C mutation of the KDM5C/JARID1C gene in one large family with X-linked intellectual disability. causal interaction,unassigned 2,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23246292&form=6&db=m A regulatory path associated with X-linked intellectual disability and epilepsy links KDM5C to the polyalanine expansions in ARX. causal interaction,unassigned 3,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23294540&form=6&db=m Haploinsufficiency of two histone modifier genes on 6p22.3, ATXN1 and JARID2, is associated with intellectual disability. causal interaction,unassigned 1,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24583395&form=6&db=m KDM5C mutational screening among males with intellectual disability suggestive of X-Linked inheritance and review of the literature. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25666439&form=6&db=m Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25858702&form=6&db=m Microdeletion of the escape genes KDM5C and IQSEC2 in a girl with severe intellectual disability and autistic features. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26804915&form=6&db=m A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation. ongoing research,therapeutic application,unassigned 1,1,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26919706&form=6&db=m Different X-linked KDM5C Mutations in Affected Male Siblings: Is Maternal Reversion Error Involved? ongoing research,unassigned 3,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27421841&form=6&db=m Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells. ongoing research,unassigned 2,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799067&form=6&db=m Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics. causal interaction,unassigned 3,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29670509&form=6&db=m Altered Gene-Regulatory Function of KDM5C by a Novel Mutation Associated With Autism and Intellectual Disability. causal interaction,unassigned 4,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30217758&form=6&db=m Novel KDM5B splice variants identified in patients with developmental disorders: Functional consequences. causal interaction,unassigned 4,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30902578&form=6&db=m Drosophila Histone Demethylase KDM5 Regulates Social Behavior through Immune Control and Gut Microbiota Maintenance. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31419599&form=6&db=m DNA methylation fingerprint of monozygotic twins and their singleton sibling with intellectual disability carrying a novel KDM5C mutation. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31691806&form=6&db=m Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32081420&form=6&db=m Mutations of histone demethylase genes encoded by X and Y chromosomes, Kdm5c and Kdm5d, lead to noncompaction cardiomyopathy in mice. causal interaction,unassigned 1,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32483278&form=6&db=m Mutually suppressive roles of KMT2A and KDM5C in behaviour, neuronal structure, and histone H3K4 methylation. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32619253&form=6&db=m [Clinical phenotype and genetic analysis of a Chinese patient featuring X-linked Claes-Jensen type syndromic mental retardation]. causal interaction,unassigned 3,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33077894&form=6&db=m JARID2 haploinsufficiency is associated with a clinically distinct neurodevelopmental syndrome. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33306820&form=6&db=m [Clinical features and gene variant of a pedigree affected with X-linked recessive mental retardation Claes-Jensen type]. unassigned - 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34530748&form=6&db=m A novel de novo KDM5C variant in a female with global developmental delay and ataxia: a case report. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Intellectual Disability http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34536985&form=6&db=m Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes-Jensen syndrome. causal interaction,unassigned 4,0 1.14.11.67 Ischemic Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28202285&form=6&db=m Decreased miR-146a expression in acute ischemic stroke directly targets the Fbxl10 mRNA and is involved in modulating apoptosis. causal interaction,unassigned 4,0 1.14.11.67 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26551685&form=6&db=m Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.11.67 Kidney Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27801678&form=6&db=m Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. ongoing research,unassigned 1,0 1.14.11.67 Klinefelter Syndrome http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30811826&form=6&db=m Epigenetics and genomics in Turner syndrome. causal interaction,unassigned 2,0 1.14.11.67 Laminopathies http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32805188&form=6&db=m Identification of Genes and Pathways Regulated by Lamin A in Heart. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Learning Disabilities http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19826449&form=6&db=m Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation. causal interaction,diagnostic usage,unassigned 1,3,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16419055&form=6&db=m Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. causal interaction,unassigned 2,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22464800&form=6&db=m The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,4,4 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22781799&form=6&db=m [The effects of JARID1B siRNA on proliferation and apoptosis in HL-60 cell]. ongoing research,unassigned 4,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23531517&form=6&db=m NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX-gene expression pattern. diagnostic usage,therapeutic application,unassigned 3,1,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105474&form=6&db=m Jarid2 is induced by TCR signalling and controls iNKT cell maturation. ongoing research,unassigned 3,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25755704&form=6&db=m JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25872778&form=6&db=m Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2. causal interaction,ongoing research,therapeutic application,unassigned 4,3,3,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25916897&form=6&db=m Keeping methylation at bay. causal interaction,therapeutic application,unassigned 2,2,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939703&form=6&db=m JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26655717&form=6&db=m Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia. causal interaction,unassigned 4,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31484620&form=6&db=m [Research Advances in Lysine-specific Demethylase 6A and Its Application in Treating Leukemia]. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Leukemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007477&form=6&db=m Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 1.14.11.67 Leukemia, Lymphoid http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939703&form=6&db=m JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Leukemia, Megakaryoblastic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23531517&form=6&db=m NUP98/JARID1A is a novel recurrent abnormality in pediatric acute megakaryoblastic leukemia with a distinct HOX-gene expression pattern. diagnostic usage,therapeutic application,unassigned 3,1,0 1.14.11.67 Leukemia, Monocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939703&form=6&db=m JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Leukemia, Myelogenous, Chronic, BCR-ABL Positive http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32007477&form=6&db=m Histone lysine demethylase KDM5B maintains chronic myeloid leukemia via multiple epigenetic actions. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,2,4,1 1.14.11.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22994852&form=6&db=m Identification and characterization of small molecule inhibitors of a plant homeodomain finger. unassigned - 1.14.11.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25655602&form=6&db=m The histone demethylase Jarid1b is required for hematopoietic stem cell self-renewal. causal interaction,unassigned 3,0 1.14.11.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29502954&form=6&db=m ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,3,4 1.14.11.67 Leukemia, Myeloid, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29602065&form=6&db=m Targeting histone demethylases KDM5A and KDM5B in AML cancer cells: A comparative view. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 1.14.11.67 Leukemia, Promyelocytic, Acute http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22781799&form=6&db=m [The effects of JARID1B siRNA on proliferation and apoptosis in HL-60 cell]. ongoing research,unassigned 4,0 1.14.11.67 Liver Cirrhosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24068189&form=6&db=m Histone demethylase retinoblastoma binding protein 2 regulates the expression of ?-smooth muscle actin and vimentin in cirrhotic livers. causal interaction,ongoing research,unassigned 1,2,0 1.14.11.67 Liver Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33621431&form=6&db=m KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21546573&form=6&db=m Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer. causal interaction,ongoing research,unassigned 1,2,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23408432&form=6&db=m Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162518&form=6&db=m Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25542019&form=6&db=m JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. ongoing research,unassigned 3,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25877751&form=6&db=m JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27224921&form=6&db=m Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27852821&form=6&db=m MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines. ongoing research,unassigned 3,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31562647&form=6&db=m Long non-coding RNA KDM5B anti-sense RNA 1 enhances tumor progression in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 2,3,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31727771&form=6&db=m The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985200&form=6&db=m Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33304897&form=6&db=m Overcoming of Radioresistance in Non-small Cell Lung Cancer by microRNA-320a Through HIF1?-Suppression Mediated Methylation of PTEN. ongoing research,unassigned 2,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33654410&form=6&db=m KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33953726&form=6&db=m Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34127738&form=6&db=m Y disruption, autosomal hypomethylation and poor male lung cancer survival. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34246759&form=6&db=m JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 1.14.11.67 Lung Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528900&form=6&db=m Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 1.14.11.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23262439&form=6&db=m JARID1B expression in human melanoma and benign melanocytic skin lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.14.11.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30092824&form=6&db=m Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 1.14.11.67 Lymphatic Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934196&form=6&db=m Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 1.14.11.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18250326&form=6&db=m Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. unassigned - 1.14.11.67 Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25755704&form=6&db=m JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.11.67 Lymphoma, B-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352142&form=6&db=m FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway. ongoing research,unassigned 3,0 1.14.11.67 Lymphoma, Large B-Cell, Diffuse http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352142&form=6&db=m FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway. ongoing research,unassigned 3,0 1.14.11.67 Lymphoma, Mantle-Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25755704&form=6&db=m JARID1B deletion induced apoptosis in Jeko-1 and HL-60 cell lines. diagnostic usage,ongoing research,unassigned 2,3,0 1.14.11.67 Medulloblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23179372&form=6&db=m OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels. unassigned - 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14639620&form=6&db=m Humoral immune response against melanoma antigens induced by vaccination with cytokine gene-modified autologous tumor cells. diagnostic usage,unassigned 3,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20478252&form=6&db=m A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20546534&form=6&db=m A role for the JARID1B stem cell marker for continuous melanoma growth. diagnostic usage,unassigned 1,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20863814&form=6&db=m Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21544224&form=6&db=m Epigenetic Regulation by Lysine Demethylase 5 (KDM5) Enzymes in Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 1,1,4,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22669717&form=6&db=m JARID1B protein expression and prognostic implications in uveal melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23262439&form=6&db=m JARID1B expression in human melanoma and benign melanocytic skin lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354547&form=6&db=m Depletion of JARID1B induces cellular senescence in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24145418&form=6&db=m Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. ongoing research,unassigned 1,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649241&form=6&db=m Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,3 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789538&form=6&db=m Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma? causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28143781&form=6&db=m Phenformin enhances the efficacy of ERK inhibition in NF1-mutant melanoma. causal interaction,unassigned 1,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29246117&form=6&db=m Prognostic significance of RBP2-H1 variant of JARID1B in melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30119689&form=6&db=m JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30523048&form=6&db=m KDM5B Promotes Drug Resistance by Regulating Melanoma-Propagating Cell Subpopulations. causal interaction,therapeutic application,unassigned 3,4,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30784290&form=6&db=m MicroRNA-363-3p/p21(Cip1/Waf1) axis is regulated by HIF-2? in mediating stemness of melanoma cells. ongoing research,unassigned 2,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31229500&form=6&db=m Targeting the H3K4 Demethylase KDM5B Reprograms the Metabolome and Phenotype of Melanoma Cells. causal interaction,diagnostic usage,therapeutic application,unassigned 1,3,1,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32731355&form=6&db=m Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908002&form=6&db=m Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 1.14.11.67 Melanoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33715247&form=6&db=m JARID1-targeted histone H3 demethylase inhibitors exhibit anti-proliferative activity and overcome cisplatin resistance in canine oral melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.11.67 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22611640&form=6&db=m Short-term memory deficits in carrier females with KDM5C mutations. causal interaction,unassigned 3,0 1.14.11.67 Memory Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26804915&form=6&db=m A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation. ongoing research,therapeutic application,unassigned 1,1,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15586325&form=6&db=m Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. causal interaction,unassigned 4,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17468742&form=6&db=m The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. causal interaction,unassigned 4,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17661819&form=6&db=m Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate. ongoing research,unassigned 2,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18697827&form=6&db=m Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20181063&form=6&db=m A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20233696&form=6&db=m [Progress on X-linked mental retardation related gene JARID1C.] causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,2,1 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182878&form=6&db=m Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26580603&form=6&db=m Mutations in the KDM5C ARID Domain and Their Plausible Association with Syndromic Claes-Jensen-Type Disease. causal interaction,unassigned 4,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27696497&form=6&db=m Cofactors-loaded quaternary structure of lysine-specific demethylase 5C (KDM5C) protein: Computational model. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799067&form=6&db=m Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics. causal interaction,unassigned 3,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30522514&form=6&db=m Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development. causal interaction,unassigned 4,0 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32392963&form=6&db=m [Two cases of X-linked mental retardation, Claes-Jensen syndrome caused by variation of KDM5C gene]. unassigned - 1.14.11.67 Mental Retardation, X-Linked http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33446955&form=6&db=m X-linked mental retardation and severe short stature with a novel mutation of the KDM5C gene. causal interaction,unassigned 4,0 1.14.11.67 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16506132&form=6&db=m [Monogenic causes of X-linked mental retardation.] causal interaction,unassigned 4,0 1.14.11.67 Microcephaly http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27799067&form=6&db=m Identification of a RAI1-associated disease network through integration of exome sequencing, transcriptomics, and 3D genomics. causal interaction,unassigned 3,0 1.14.11.67 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27488530&form=6&db=m JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers. unassigned - 1.14.11.67 Mouth Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29247040&form=6&db=m Correction: JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers. unassigned - 1.14.11.67 Movement Disorders http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34530748&form=6&db=m A novel de novo KDM5C variant in a female with global developmental delay and ataxia: a case report. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Multiple Endocrine Neoplasia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788502&form=6&db=m Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. causal interaction,therapeutic application,unassigned 2,3,0 1.14.11.67 Multiple Endocrine Neoplasia Type 1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788502&form=6&db=m Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. causal interaction,therapeutic application,unassigned 2,3,0 1.14.11.67 Multiple Myeloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34258103&form=6&db=m Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma. ongoing research,unassigned 2,0 1.14.11.67 Myelodysplastic Syndromes http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22308277&form=6&db=m Polycomb segment myeloid malignancies. unassigned - 1.14.11.67 Myocardial Infarction http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32056726&form=6&db=m Protective effect of FBXL10 in myocardial ischemia reperfusion injury via inhibiting endoplasmic reticulum stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Myocardial Ischemia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32056726&form=6&db=m Protective effect of FBXL10 in myocardial ischemia reperfusion injury via inhibiting endoplasmic reticulum stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26458315&form=6&db=m FBXL10 contributes to the progression of nasopharyngeal carcinoma via involving in PI3K/mTOR pathway. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34218325&form=6&db=m Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-181a retards nasopharyngeal carcinoma development by mediating KDM5C. diagnostic usage,ongoing research,unassigned 1,3,0 1.14.11.67 Nasopharyngeal Carcinoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34385569&form=6&db=m Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion. causal interaction,diagnostic usage,ongoing research,unassigned 1,4,2,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21937684&form=6&db=m Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23262439&form=6&db=m JARID1B expression in human melanoma and benign melanocytic skin lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23321669&form=6&db=m KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435416&form=6&db=m JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells. diagnostic usage,therapeutic application,unassigned 2,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25628922&form=6&db=m KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909289&form=6&db=m JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182878&form=6&db=m Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26503415&form=6&db=m Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917489&form=6&db=m Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259236&form=6&db=m JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27548814&form=6&db=m Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27974677&form=6&db=m Histone demethylase lysine demethylase 5B in development and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714012&form=6&db=m Knockdown of JARID2 inhibits the viability and migration of placenta trophoblast cells in preeclampsia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714030&form=6&db=m KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324315&form=6&db=m Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29754934&form=6&db=m Comprehensive Genomic Profiling of Metastatic Tumors in a Phase 2 Biomarker Study of Everolimus in Advanced Renal Cell Carcinoma. unassigned - 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30092824&form=6&db=m Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30650517&form=6&db=m Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864186&form=6&db=m KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30978340&form=6&db=m KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31727771&form=6&db=m The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805991&form=6&db=m Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934196&form=6&db=m Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32097694&form=6&db=m Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma. diagnostic usage,unassigned 2,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32196595&form=6&db=m ETV4 promotes the progression of gastric cancer through regulating KDM5D. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32477467&form=6&db=m Correction: JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. causal interaction,unassigned 2,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32651355&form=6&db=m Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1. causal interaction,unassigned 1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714863&form=6&db=m KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850370&form=6&db=m LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT. unassigned - 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33436536&form=6&db=m Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33499904&form=6&db=m Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33654410&form=6&db=m KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Neoplasm Metastasis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34276383&form=6&db=m Evidence of Omics, Immune Infiltration, and Pharmacogenomic for SENP1 in the Pan-Cancer Cohort. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,1,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9448297&form=6&db=m p21WAF-1 reorganizes the nucleus in tumor suppression. ongoing research,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10336460&form=6&db=m A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. causal interaction,ongoing research,unassigned 1,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12237901&form=6&db=m PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen? causal interaction,ongoing research,unassigned 3,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12530026&form=6&db=m Relevance of c-erbB2, PLU-1 and survivin mRNA expression to diagnostic assessment of breast cancer. diagnostic usage,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12617814&form=6&db=m Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12657635&form=6&db=m Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14516692&form=6&db=m Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14579128&form=6&db=m PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17320163&form=6&db=m The retinoblastoma binding protein RBP2 is an H3K4 demethylase. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17363312&form=6&db=m PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18591252&form=6&db=m The histone demethylase KDM5b/JARID1b plays a role in cell fate decisions by blocking terminal differentiation. causal interaction,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19336002&form=6&db=m The PcG protein hPc2 interacts with the N-terminus of histone demethylase JARID1B and acts as a transcriptional co-repressor. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19759154&form=6&db=m Reticuloendotheliosis virus strain T induces miR-155 which targets JARID2 and promotes cell survival. diagnostic usage,ongoing research,unassigned 3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226085&form=6&db=m Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20406991&form=6&db=m Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20478252&form=6&db=m A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20863814&form=6&db=m Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20959362&form=6&db=m Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation, in part, via transcriptional repression of histone H3 lysine 4 demethylases. causal interaction,ongoing research,unassigned 3,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20973793&form=6&db=m New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21248752&form=6&db=m Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21252908&form=6&db=m F-box protein 10, an NF-?B-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway. diagnostic usage,ongoing research,therapeutic application,unassigned 1,1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21369698&form=6&db=m PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 4,4,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21402699&form=6&db=m Endothelial Jarid2/Jumonji is required for normal cardiac development and proper Notch1 expression. causal interaction,therapeutic application,unassigned 3,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21725364&form=6&db=m The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C. causal interaction,unassigned 4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788502&form=6&db=m Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. causal interaction,therapeutic application,unassigned 2,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21937684&form=6&db=m Binding of the JmjC demethylase JARID1B to LSD1/NuRD suppresses angiogenesis and metastasis in breast cancer cells by repressing chemokine CCL14. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21969366&form=6&db=m Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e. causal interaction,ongoing research,therapeutic application,unassigned 4,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22113291&form=6&db=m Evaluation of histone-modifying enzymes in stem cell populations. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22156295&form=6&db=m Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22190018&form=6&db=m Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies. causal interaction,unassigned 4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22249190&form=6&db=m Epigenetic regulation in RCC: opportunities for therapeutic intervention? causal interaction,unassigned 1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22308277&form=6&db=m Polycomb segment myeloid malignancies. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22353921&form=6&db=m [Application of human adipose-derived stromal cells in bone tissue engineering]. causal interaction,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22468166&form=6&db=m Effects of Histone Deacetylase Inhibitors on Modulating H3K4 Methylation Marks - A Novel Cross-Talk Mechanism between Histone-Modifying Enzymes. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22534467&form=6&db=m Overexpression of Jumonji AT-rich interactive domain 1B and PHD finger protein 2 is involved in the progression of esophageal squamous cell carcinoma. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22615382&form=6&db=m H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22669717&form=6&db=m JARID1B protein expression and prognostic implications in uveal melanoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,1,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22937203&form=6&db=m Genomic amplification and a role in drug-resistance for the KDM5A histone demethylase in breast cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22949125&form=6&db=m Loss of PBRM1 expression is associated with renal cell carcinoma progression. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23262439&form=6&db=m JARID1B expression in human melanoma and benign melanocytic skin lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23314859&form=6&db=m Positive Expression of LSD1 and Negative Expression of E-cadherin Correlate with Metastasis and Poor Prognosis of Colon Cancer. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23354547&form=6&db=m Depletion of JARID1B induces cellular senescence in human colorectal cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23408432&form=6&db=m Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23579952&form=6&db=m Connexin 26 is Down-Regulated by KDM5B in the Progression of Bladder Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23644518&form=6&db=m Aberrant promoter hypermethylation of PBRM1, BAP1, SETD2, KDM6A and other chromatin-modifying genes is absent or rare in clear cell RCC. diagnostic usage,ongoing research,unassigned 3,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23759590&form=6&db=m KDM5B histone demethylase controls epithelial-mesenchymal transition of cancer cells by regulating the expression of the microRNA-200 family. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,3,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24098529&form=6&db=m The Human Melanoma Side Population Displays Molecular and Functional Characteristics of Enriched Chemoresistance and Tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24425785&form=6&db=m Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24481781&form=6&db=m Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein. ongoing research,therapeutic application,unassigned 4,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24649241&form=6&db=m Jumonji/Arid1b (Jarid1b) protein modulates human esophageal cancer cell growth. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,1,1,3 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24952722&form=6&db=m The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016185&form=6&db=m KDM5C is overexpressed in prostate cancer and is a prognostic marker for prostate-specific antigen-relapse following radical prostatectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25097177&form=6&db=m miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25111482&form=6&db=m The KDM5 family of histone demethylases as targets in oncology drug discovery. causal interaction,ongoing research,therapeutic application,unassigned 1,3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25124064&form=6&db=m The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162518&form=6&db=m Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25450384&form=6&db=m Overexpressed KDM5B is associated with the progression of glioma and promotes glioma cell growth via downregulating p21. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25596733&form=6&db=m SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25609834&form=6&db=m Impairment of Preimplantation Porcine Embryo Development by Histone Demethylase KDM5B Knockdown Through Disturbance of Bivalent H3K4me3-H3K27me3 Modifications. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25628922&form=6&db=m KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25663457&form=6&db=m Overexpression of JARID1B is associated with poor prognosis and chemotherapy resistance in epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25755053&form=6&db=m cis-Cyclopropylamines as mechanism-based inhibitors of Monoamine Oxidases. therapeutic application,unassigned 4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25789538&form=6&db=m Altered Splicing of JARID1B in Development of Human Cutaneous Melanoma? causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25873528&form=6&db=m The roles of chromatin-remodelers and epigenetic modifiers in kidney cancer. causal interaction,ongoing research,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25877751&form=6&db=m JARID1B modulates lung cancer cell proliferation and invasion by regulating p53 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909289&form=6&db=m JARID1B promotes metastasis and epithelial-mesenchymal transition via PTEN/AKT signaling in hepatocellular carcinoma cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25939703&form=6&db=m JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25951238&form=6&db=m JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells. causal interaction,ongoing research,unassigned 1,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25956476&form=6&db=m Expression of Lysine-specific demethylase 1 in human epithelial ovarian cancer. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26062444&form=6&db=m Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26125737&form=6&db=m Immunohistochemical detection and clinicopathological significance of JARID1B/KDM5B and P16 expression in invasive ductal carcinoma of the breast. diagnostic usage,ongoing research,unassigned 1,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26131109&form=6&db=m MiR-29a suppresses prostate cell proliferation and induces apoptosis via KDM5B protein regulation. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26182878&form=6&db=m Histone demethylase JARID1C promotes breast cancer metastasis cells via down regulating BRMS1 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,3 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26184998&form=6&db=m Silencing JARID1B suppresses oncogenicity, stemness and increases radiation sensitivity in human oral carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26314709&form=6&db=m Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells. causal interaction,diagnostic usage,ongoing research,unassigned 4,3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26461474&form=6&db=m MiR137 is an androgen regulated repressor of an extended network of transcriptional coregulators. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26484545&form=6&db=m Gender Specific Mutation Incidence and Survival Associations in Clear Cell Renal Cell Carcinoma (CCRCC). causal interaction,unassigned 4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26503415&form=6&db=m Lysine-specific demethylase 5C promotes hepatocellular carcinoma cell invasion through inhibition BMP7 expression. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,2,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26527083&form=6&db=m Metastatic renal cell carcinoma without evidence of a renal primary. diagnostic usage,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26551685&form=6&db=m Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,1,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26645689&form=6&db=m Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases. ongoing research,therapeutic application,unassigned 1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26858085&form=6&db=m Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26911146&form=6&db=m Depletion of histone demethylase KDM5B inhibits cell proliferation of hepatocellular carcinoma by regulation of cell cycle checkpoint proteins p15 and p27. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26917489&form=6&db=m Aberrant KDM5B expression promotes aggressive breast cancer through MALAT1 overexpression and downregulation of hsa-miR-448. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27037751&form=6&db=m Inhibitors of DNA Methylation, Histone Deacetylation, and Histone Demethylation: A Perfect Combination for Cancer Therapy. causal interaction,therapeutic application,unassigned 3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27224921&form=6&db=m Screen-identified selective inhibitor of lysine demethylase 5A blocks cancer cell growth and drug resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27246838&form=6&db=m Jumonji AT-rich interactive domain 1B overexpression is associated with the development and progression of glioma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27253695&form=6&db=m Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair. ongoing research,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27259236&form=6&db=m JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling. causal interaction,diagnostic usage,therapeutic application,unassigned 4,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27292631&form=6&db=m PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer. causal interaction,therapeutic application,unassigned 3,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27548814&form=6&db=m Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype. causal interaction,ongoing research,therapeutic application,unassigned 3,3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27584795&form=6&db=m Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27626165&form=6&db=m Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27641964&form=6&db=m Reduced expression of Jumonji, AT-rich interactive domain 2 (JARID2) in glioma inhibits tumor growth in vitro and in vivo. causal interaction,ongoing research,therapeutic application,unassigned 4,4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27852821&form=6&db=m MEG3 Long Noncoding RNA Contributes to the Epigenetic Regulation of Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines. ongoing research,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27874950&form=6&db=m miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27974677&form=6&db=m Histone demethylase lysine demethylase 5B in development and cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,3,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28212566&form=6&db=m Genetic characterization of Polish ccRCC patients: somatic mutation analysis of PBRM1, BAP1 and KDMC5, genomic SNP array analysis in tumor biopsy and preliminary results of chromosome aberrations analysis in plasma cell free DNA. diagnostic usage,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28302961&form=6&db=m Getting to the heart of the matter in cancer: Novel approaches to targeting cancer stem cells. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28422711&form=6&db=m Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445934&form=6&db=m Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28492139&form=6&db=m Histone Demethylase JARID1B is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression Via Demethylation of H3K27me3. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28753749&form=6&db=m Comprehensive Genomic Profiling of Renal Cell Carcinoma at Initial Diagnosis and Putative Local Recurrence. causal interaction,unassigned 1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28783174&form=6&db=m Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28827149&form=6&db=m Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28958389&form=6&db=m JARID1 Histone Demethylases: Emerging Targets in Cancer. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29058709&form=6&db=m Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA. ongoing research,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29132830&form=6&db=m Characterizing recurrent and lethal small renal masses in clear cell renal cell carcinoma using recurrent somatic mutations. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29196338&form=6&db=m Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29246117&form=6&db=m Prognostic significance of RBP2-H1 variant of JARID1B in melanoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29282222&form=6&db=m A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2'-Deoxycytidine. causal interaction,ongoing research,therapeutic application,unassigned 4,1,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29324315&form=6&db=m Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29339538&form=6&db=m E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29352142&form=6&db=m FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway. ongoing research,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29442054&form=6&db=m mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia. ongoing research,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507668&form=6&db=m Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29602065&form=6&db=m Targeting histone demethylases KDM5A and KDM5B in AML cancer cells: A comparative view. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,1,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29683067&form=6&db=m Lysine-specific demethylase 2A expression is associated with cell growth and cyclin D1 expression in colorectal adenocarcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29863497&form=6&db=m ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29928411&form=6&db=m Jumonji AT-rich interactive domain 1B promotes the growth of pancreatic tumors via the phosphatase and tensin homolog/protein kinase B signaling pathway. causal interaction,ongoing research,therapeutic application,unassigned 4,2,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29989047&form=6&db=m KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance. ongoing research,therapeutic application,unassigned 1,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30030490&form=6&db=m Epigenetic modifiers: activities in renal cell carcinoma. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30068733&form=6&db=m Endometrial cancer with an EML4-ALK rearrangement. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30080846&form=6&db=m KDM5 histone demethylases repress immune response via suppression of STING. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30092824&form=6&db=m Histone demethylase JARID1B/KDM5B promotes aggressiveness of non-small cell lung cancer and serves as a good prognostic predictor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,2 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30119689&form=6&db=m JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30257334&form=6&db=m KDM5c inhibits multidrug resistance of colon cancer cell line by down-regulating ABCC1. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,3 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30343192&form=6&db=m Lysine demethylase 5B (KDM5B): A potential anti-cancer drug target. causal interaction,therapeutic application,unassigned 3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30353907&form=6&db=m Increased Expression of Lysine-Specific Demethylase 5B (KDM5B) Promotes Tumor Cell Growth in Hep3B Cells and is an Independent Prognostic Factor in Patients with Hepatocellular Carcinoma. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30355483&form=6&db=m Jumonji Inhibitors Overcome Radioresistance in Cancer through Changes in H3K4 Methylation at Double-Strand Breaks. diagnostic usage,ongoing research,therapeutic application,unassigned 2,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30388705&form=6&db=m KDM5A Regulates a Translational Program that Controls p53 Protein Expression. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30416077&form=6&db=m Genomically annotated risk model for advanced renal-cell carcinoma: a retrospective cohort study. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30423295&form=6&db=m JARID2 Functions as a Tumor Suppressor in Myeloid Neoplasms by Repressing Self-Renewal in Hematopoietic Progenitor Cells. ongoing research,therapeutic application,unassigned 1,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30448242&form=6&db=m KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer. causal interaction,ongoing research,unassigned 3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30504238&form=6&db=m JARID2 Is a Tumor Suppressor in Myeloid Neoplasms. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30522514&form=6&db=m Physiological effects of KDM5C on neural crest migration and eye formation during vertebrate development. causal interaction,unassigned 4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30622286&form=6&db=m Tubulocystic renal cell carcinoma: a distinct clinicopathologic entity with a characteristic genomic profile. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30626866&form=6&db=m Histone H3 binding to the PHD1 domain of histone demethylase KDM5A enables active site remodeling. therapeutic application,unassigned 1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30650517&form=6&db=m Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864186&form=6&db=m KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30866496&form=6&db=m Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30978340&form=6&db=m KDM5B promotes breast cancer cell proliferation and migration via AMPK-mediated lipid metabolism reprogramming. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,1,3,3 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31221981&form=6&db=m The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31308693&form=6&db=m LSD1 regulates Notch and PI3K/Akt/mTOR pathways through binding the promoter regions of Notch target genes in esophageal squamous cell carcinoma. causal interaction,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350278&form=6&db=m Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31562647&form=6&db=m Long non-coding RNA KDM5B anti-sense RNA 1 enhances tumor progression in non-small cell lung cancer. causal interaction,diagnostic usage,unassigned 2,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31641207&form=6&db=m A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. causal interaction,diagnostic usage,ongoing research,unassigned 1,1,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31727771&form=6&db=m The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,2,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776402&form=6&db=m Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31805991&form=6&db=m Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934196&form=6&db=m Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985200&form=6&db=m Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32097694&form=6&db=m Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma. diagnostic usage,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32117236&form=6&db=m Transcriptomic Features of T Cell-Barren Tumors Are Conserved Across Diverse Tumor Types. causal interaction,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32147429&form=6&db=m KDM5B-mediated microRNA-448 up-regulation restrains papillary thyroid cancer cell progression and slows down tumor growth via TGIF1 repression. causal interaction,ongoing research,unassigned 1,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32155529&form=6&db=m Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B). causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32392781&form=6&db=m Prediction of High-Grade Clear Cell Renal Cell Carcinoma Based on Plasma mRNA Profiles in Patients with Localized Pathologic T1N0M0 Stage Disease. diagnostic usage,ongoing research,unassigned 3,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32714863&form=6&db=m KDM5C Represses FASN-Mediated Lipid Metabolism to Exert Tumor Suppressor Activity in Intrahepatic Cholangiocarcinoma. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32731355&form=6&db=m Study of the Female Sex Survival Advantage in Melanoma-A Focus on X-Linked Epigenetic Regulators and Immune Responses in Two Cohorts. causal interaction,diagnostic usage,ongoing research,unassigned 3,4,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32751840&form=6&db=m Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32754863&form=6&db=m In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,2,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32805188&form=6&db=m Identification of Genes and Pathways Regulated by Lamin A in Heart. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32850370&form=6&db=m LSD1 Promotes Bladder Cancer Progression by Upregulating LEF1 and Enhancing EMT. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863895&form=6&db=m Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32868382&form=6&db=m KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32883639&form=6&db=m Targeting histone demethylase KDM5B for cancer treatment. diagnostic usage,therapeutic application,unassigned 2,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32908002&form=6&db=m Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade. causal interaction,diagnostic usage,therapeutic application,unassigned 3,3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32918895&form=6&db=m Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061611&form=6&db=m microRNA-139-3p Inhibits Malignant Behaviors of Laryngeal Cancer Cells via the KDM5B/SOX2 Axis and the Wnt/?-Catenin Pathway. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087165&form=6&db=m Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33109187&form=6&db=m JARID1B promotes colorectal cancer proliferation and Wnt/?-catenin signaling via decreasing CDX2 level. causal interaction,diagnostic usage,ongoing research,unassigned 2,3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117625&form=6&db=m Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways. causal interaction,unassigned 2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33145271&form=6&db=m Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer. causal interaction,ongoing research,unassigned 4,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33160990&form=6&db=m Lysine demethylase 5B suppresses CC chemokine ligand 14 to promote progression of colorectal cancer through the Wnt/?-catenin pathway. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245716&form=6&db=m Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33436536&form=6&db=m Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470543&form=6&db=m Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5?C Degraders. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33596982&form=6&db=m The emerging role of KDM5A in human cancer. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33621062&form=6&db=m Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33621431&form=6&db=m KDM5A silencing transcriptionally suppresses the FXYD3-PI3K/AKT axis to inhibit angiogenesis in hepatocellular cancer via miR-433 up-regulation. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33654410&form=6&db=m KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33715247&form=6&db=m JARID1-targeted histone H3 demethylase inhibitors exhibit anti-proliferative activity and overcome cisplatin resistance in canine oral melanoma cell lines. causal interaction,ongoing research,therapeutic application,unassigned 4,2,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33823929&form=6&db=m Association between visceral adiposity and DDX11 as a predictor of aggressiveness of small clear-cell renal-cell carcinoma: a prospective clinical trial. causal interaction,diagnostic usage,ongoing research,unassigned 2,2,2,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33829656&form=6&db=m KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854217&form=6&db=m Targeting KDM1B-dependent miR-215-AR-AGR2-axis promotes sensitivity to enzalutamide-resistant prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854980&form=6&db=m Personalized Survival Prediction of Patients With Acute Myeloblastic Leukemia Using Gene Expression Profiling. diagnostic usage,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33941612&form=6&db=m Inhibition of Jumonji Histone Demethylases Selectively Suppresses HER2+ Breast Leptomeningeal Carcinomatosis Growth via Inhibition of GMCSF Expression. ongoing research,unassigned 1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33953726&form=6&db=m Predictive Value of KDM5C Alterations for Immune Checkpoint Inhibitors Treatment Outcomes in Patients With Cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,4 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33994165&form=6&db=m Correlating Immune Cell Infiltration Patterns with Recurrent Somatic Mutations in Advanced Clear Cell Renal Cell Carcinoma. causal interaction,unassigned 4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34100557&form=6&db=m Histone demethylase PHF8 promotes cell growth and metastasis of non-small-cell lung cancer through activating Wnt/?-catenin signaling pathway. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34127738&form=6&db=m Y disruption, autosomal hypomethylation and poor male lung cancer survival. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34143366&form=6&db=m microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C. ongoing research,unassigned 1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34184733&form=6&db=m KDM5A and KDM5B histone-demethylases contribute to HU-induced replication stress response and tolerance. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34218325&form=6&db=m Human umbilical cord mesenchymal stem cells-derived exosomal microRNA-181a retards nasopharyngeal carcinoma development by mediating KDM5C. diagnostic usage,ongoing research,unassigned 1,3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34240323&form=6&db=m microRNA-206 Suppresses Cholangiocarcinoma Cell Growth and Invasion by Targeting Jumonji AT-Rich Interactive Domain 2. diagnostic usage,ongoing research,therapeutic application,unassigned 4,2,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34246759&form=6&db=m JARID2 promotes stemness and cisplatin resistance in non-small cell lung cancer via upregulation of Notch1. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,4,2 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34249685&form=6&db=m Genomic Landscape of Chinese Clear Cell Renal Cell Carcinoma Patients With Venous Tumor Thrombus Identifies Chromosome 9 and 14 Deletions and Related Immunosuppressive Microenvironment. diagnostic usage,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34327974&form=6&db=m microRNA-486-5p functions as a tumor suppressor in gastric carcinoma via directly targeting KDM5B. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34437163&form=6&db=m JARID2 Is a Tumor Suppressor in Myeloid Neoplasms. causal interaction,unassigned 3,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34494305&form=6&db=m LncRNA TNK2-AS1/miR-125a-5p axis promotes tumor growth and modulated PI3K/AKT pathway. unassigned - 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34522206&form=6&db=m Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34528900&form=6&db=m Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells. ongoing research,therapeutic application,unassigned 4,1,0 1.14.11.67 Neoplasms, Squamous Cell http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27584795&form=6&db=m Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21220025&form=6&db=m Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. causal interaction,unassigned 3,0 1.14.11.67 Neural Tube Defects http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23637629&form=6&db=m The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. therapeutic application,unassigned 1,0 1.14.11.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24481781&form=6&db=m Histone demethylase JARID1B promotes cell proliferation but is downregulated by N-Myc oncoprotein. ongoing research,therapeutic application,unassigned 4,2,0 1.14.11.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25951238&form=6&db=m JARID1B Expression Plays a Critical Role in Chemoresistance and Stem Cell-Like Phenotype of Neuroblastoma Cells. causal interaction,ongoing research,unassigned 1,2,0 1.14.11.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26062444&form=6&db=m Lysine-specific demethylase (LSD1/KDM1A) and MYCN cooperatively repress tumor suppressor genes in neuroblastoma. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27421841&form=6&db=m Patient Mutations of the Intellectual Disability Gene KDM5C Downregulate Netrin G2 and Suppress Neurite Growth in Neuro2a Cells. ongoing research,unassigned 2,0 1.14.11.67 Neuroblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28783174&form=6&db=m Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Nevus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23262439&form=6&db=m JARID1B expression in human melanoma and benign melanocytic skin lesions. causal interaction,diagnostic usage,ongoing research,unassigned 4,4,4,0 1.14.11.67 Osteopetrosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30401973&form=6&db=m Diversity of copy number variation in the worldwide goat population. unassigned - 1.14.11.67 Osteoporosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27512956&form=6&db=m KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,3,2 1.14.11.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28492139&form=6&db=m Histone Demethylase JARID1B is Overexpressed in Osteosarcoma and Upregulates Cyclin D1 Expression Via Demethylation of H3K27me3. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Osteosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33436536&form=6&db=m Histone demethylase KDM5A promotes tumorigenesis of osteosarcoma tumor. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,1 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27694900&form=6&db=m Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,1 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714030&form=6&db=m KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765957&form=6&db=m Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,1,4,4 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28925393&form=6&db=m Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance. diagnostic usage,ongoing research,unassigned 1,1,0 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30409964&form=6&db=m miR-146b promotes cell proliferation and increases chemosensitivity, but attenuates cell migration and invasion via FBXL10 in ovarian cancer. causal interaction,unassigned 2,0 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31108893&form=6&db=m Promotion of Cell Death in Cisplatin-Resistant Ovarian Cancer Cells through KDM1B-DCLRE1B Modulation. causal interaction,therapeutic application,unassigned 1,4,0 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32329828&form=6&db=m MiR-135b-5p affected malignant behaviors of ovarian cancer cells by targeting KDM5B. causal interaction,unassigned 2,0 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33061428&form=6&db=m Targeting of KDM5A by miR-421 in Human Ovarian Cancer Suppresses the Progression of Ovarian Cancer Cells. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,3,0 1.14.11.67 Ovarian Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33275209&form=6&db=m MiR-135b-5p affected malignant behaviors of ovarian cancer cells by targeting KDM5B. causal interaction,unassigned 2,0 1.14.11.67 Pancreatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30846414&form=6&db=m Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells. causal interaction,ongoing research,therapeutic application,unassigned 1,3,2,0 1.14.11.67 Papilloma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30080846&form=6&db=m KDM5 histone demethylases repress immune response via suppression of STING. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.11.67 Persistent Infection http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31350278&form=6&db=m Blockade of Immune-Checkpoint B7-H4 and Lysine Demethylase 5B in Esophageal Squamous Cell Carcinoma Confers Protective Immunity against P. gingivalis Infection. causal interaction,diagnostic usage,ongoing research,unassigned 1,3,4,0 1.14.11.67 Pinealoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27282397&form=6&db=m Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome. causal interaction,unassigned 3,0 1.14.11.67 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714012&form=6&db=m Knockdown of JARID2 inhibits the viability and migration of placenta trophoblast cells in preeclampsia. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.14.11.67 Pre-Eclampsia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29546425&form=6&db=m Redox-Sensitive Transcription Factor NRF2 Enhances Trophoblast Differentiation via Induction of miR-1246 and Aromatase. causal interaction,therapeutic application,unassigned 3,3,0 1.14.11.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29565495&form=6&db=m Down-regulation of JARID1B expression inhibits cell proliferation, induces apoptosis and blocks cell cycle in human acute lymphoblastic leukemia cells. causal interaction,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.11.67 Precursor Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31206203&form=6&db=m MiR-137 inhibits cell proliferation in acute lymphoblastic leukemia by targeting JARID1B. ongoing research,unassigned 2,0 1.14.11.67 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34162697&form=6&db=m Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes. ongoing research,therapeutic application,unassigned 3,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18048344&form=6&db=m JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,2,1 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23408432&form=6&db=m Identification of Small Molecule Inhibitors of Jumonji AT-rich Interactive Domain 1B (JARID1B) Histone Demethylase by a Sensitive High Throughput Screen. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25016185&form=6&db=m KDM5C is overexpressed in prostate cancer and is a prognostic marker for prostate-specific antigen-relapse following radical prostatectomy. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25596733&form=6&db=m SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26215926&form=6&db=m Two Splice Variants of Y Chromosome-Located Lysine-Specific Demethylase 5D Have Distinct Function in Prostate Cancer Cell Line (DU-145). diagnostic usage,ongoing research,therapeutic application,unassigned 1,4,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26728332&form=6&db=m Investigation of Histone Lysine-Specific Demethylase 5D KDM5D) Isoform Expression in Prostate Cancer Cell Lines: a System Approach. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26747897&form=6&db=m JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis. ongoing research,therapeutic application,unassigned 2,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27185910&form=6&db=m Resistance to docetaxel in prostate cancer is associated with androgen receptor activation and loss of KDM5D expression. causal interaction,ongoing research,therapeutic application,unassigned 4,3,2,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27979512&form=6&db=m Re: Resistance to Docetaxel in Prostate Cancer is Associated with Androgen Receptor Activation and Loss of KDM5D Expression. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29863497&form=6&db=m ATR inhibition controls aggressive prostate tumors deficient in Y-linked histone demethylase KDM5D. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,2,4 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30446585&form=6&db=m AKT Inhibition Modulates H3K4 Demethylase Levels in PTEN-Null Prostate Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30921702&form=6&db=m KDM5C is transcriptionally regulated by BRD4 and promotes castration-resistance prostate cancer cell proliferation by repressing PTEN. causal interaction,unassigned 2,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985200&form=6&db=m Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32751840&form=6&db=m Histone Demethylase KDM5B as a Therapeutic Target for Cancer Therapy. causal interaction,diagnostic usage,therapeutic application,unassigned 4,2,4,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32863895&form=6&db=m Analysis of key genes reveal lysine demethylase 5B promotes prostate cancer progression. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,3,4,1 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32868382&form=6&db=m KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33087165&form=6&db=m Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression. diagnostic usage,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33245716&form=6&db=m Evidence for context-dependent functions of KDM5B in prostate development and prostate cancer. causal interaction,diagnostic usage,unassigned 4,3,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33470543&form=6&db=m Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5?C Degraders. causal interaction,diagnostic usage,therapeutic application,unassigned 3,1,4,0 1.14.11.67 Prostatic Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33854217&form=6&db=m Targeting KDM1B-dependent miR-215-AR-AGR2-axis promotes sensitivity to enzalutamide-resistant prostate cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,4,0 1.14.11.67 Reflex, Abnormal http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18697827&form=6&db=m Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 Renal Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31682847&form=6&db=m The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 1.14.11.67 Reperfusion Injury http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32056726&form=6&db=m Protective effect of FBXL10 in myocardial ischemia reperfusion injury via inhibiting endoplasmic reticulum stress. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Respiratory Insufficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23637629&form=6&db=m The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3. therapeutic application,unassigned 1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7935440&form=6&db=m Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. diagnostic usage,ongoing research,therapeutic application,unassigned 1,3,1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8253384&form=6&db=m Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. ongoing research,unassigned 1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8530100&form=6&db=m Isolation and regional assignment of human chromosome 12p cDNAs. ongoing research,unassigned 2,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10760505&form=6&db=m An ARID family protein binds to the African swine fever virus encoded ubiquitin conjugating enzyme, UBCv1. unassigned - 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10878660&form=6&db=m Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). ongoing research,unassigned 3,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11014813&form=6&db=m A screen for new trithorax group genes identified little imaginal discs, the Drosophila melanogaster homologue of human retinoblastoma binding protein 2. ongoing research,unassigned 1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11029697&form=6&db=m A protein with similarity to the human retinoblastoma binding protein 2 acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis. ongoing research,therapeutic application,unassigned 2,1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16419055&form=6&db=m Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene. causal interaction,unassigned 2,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17320163&form=6&db=m The retinoblastoma binding protein RBP2 is an H3K4 demethylase. unassigned - 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21575435&form=6&db=m [Inhibition of retinoblastoma binding protein 2 promotes osteogenic differentiation of human adipose-derived stromal cells]. ongoing research,unassigned 3,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21604327&form=6&db=m Inhibition of osteogenic differentiation of human adipose-derived stromal cells by retinoblastoma binding protein 2 repression of RUNX2-activated transcription. ongoing research,therapeutic application,unassigned 3,1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21788502&form=6&db=m Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. causal interaction,therapeutic application,unassigned 2,3,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22353921&form=6&db=m [Application of human adipose-derived stromal cells in bone tissue engineering]. causal interaction,unassigned 2,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22615382&form=6&db=m H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. unassigned - 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23000338&form=6&db=m Crosstalk between VEGF and novel angiogenic protein regulates tumor angiogenesis and contributes to aggressiveness of breast carcinoma. diagnostic usage,ongoing research,unassigned 1,1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23794145&form=6&db=m MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2. causal interaction,unassigned 2,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23922798&form=6&db=m Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24068189&form=6&db=m Histone demethylase retinoblastoma binding protein 2 regulates the expression of ?-smooth muscle actin and vimentin in cirrhotic livers. causal interaction,ongoing research,unassigned 1,2,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24716659&form=6&db=m Critical role of histone demethylase RBP2 in human gastric cancer angiogenesis. causal interaction,ongoing research,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25162518&form=6&db=m Retinoblastoma binding protein 2 (RBP2) promotes HIF-1?-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway. causal interaction,diagnostic usage,ongoing research,unassigned 3,3,2,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25468371&form=6&db=m The nanoscale geometry of TiO2 nanotubes influences the osteogenic differentiation of human adipose-derived stem cells by modulating H3K4 trimethylation. unassigned - 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25686748&form=6&db=m Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. ongoing research,therapeutic application,unassigned 1,1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26788140&form=6&db=m siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells. ongoing research,unassigned 4,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27453008&form=6&db=m MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network. diagnostic usage,unassigned 3,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28970247&form=6&db=m Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation. unassigned - 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31578284&form=6&db=m JARID2 and the PRC2 complex regulate the cell cycle in skeletal muscle. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Retinoblastoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32805188&form=6&db=m Identification of Genes and Pathways Regulated by Lamin A in Heart. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 Rhabdomyosarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23435416&form=6&db=m JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells. diagnostic usage,therapeutic application,unassigned 2,1,0 1.14.11.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22245111&form=6&db=m Lysine-specific demethylase 1 (LSD1/KDM1A/AOF2/BHC110) is expressed and is an epigenetic drug target in chondrosarcoma, Ewing's sarcoma, osteosarcoma, and rhabdomyosarcoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Sarcoma http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34453478&form=6&db=m In vivo evaluation of the lysine-specific demethylase (KDM1A/LSD1) inhibitor SP-2577 (Seclidemstat) against pediatric sarcoma preclinical models: A report from the Pediatric Preclinical Testing Consortium (PPTC). therapeutic application,unassigned 3,0 1.14.11.67 Sarcoma, Ewing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33196691&form=6&db=m KDM5A and PHF2 positively control expression of pro-metastatic genes repressed by EWS/Fli1, and promote growth and metastatic properties in Ewing sarcoma. ongoing research,therapeutic application,unassigned 1,3,0 1.14.11.67 Seizures http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25652354&form=6&db=m Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability. causal interaction,unassigned 4,0 1.14.11.67 Sepsis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31682847&form=6&db=m The therapeutic effect of dexmedetomidine on protection from renal failure via inhibiting KDM5A in lipopolysaccharide-induced sepsis of mice. causal interaction,ongoing research,therapeutic application,unassigned 2,3,3,0 1.14.11.67 Skin Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22420752&form=6&db=m Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor. causal interaction,diagnostic usage,therapeutic application,unassigned 4,1,4,0 1.14.11.67 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21562575&form=6&db=m The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis. diagnostic usage,unassigned 2,0 1.14.11.67 Spondylitis, Ankylosing http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24069348&form=6&db=m JARID1A, JMY, and PTGER4 Polymorphisms Are Related to Ankylosing Spondylitis in Chinese Han Patients: A Case-Control Study. ongoing research,therapeutic application,unassigned 3,1,0 1.14.11.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23714058&form=6&db=m [Sonic hedgehog signaling enhanced the expression of histone demethylase, lysine-specific demethylase 8 in the head and neck squamous cell carcinoma cell line SCC-6]. causal interaction,ongoing research,unassigned 1,3,0 1.14.11.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24425785&form=6&db=m Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,2,4 1.14.11.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27584795&form=6&db=m Overexpression of JARID1B promotes differentiation via SHIP1/AKT signaling in human hypopharyngeal squamous cell carcinoma. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0 1.14.11.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29507668&form=6&db=m Targeting JARID1B's demethylase activity blocks a subset of its functions in oral cancer. causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Squamous Cell Carcinoma of Head and Neck http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31934196&form=6&db=m Prognostic value of elevated KDM5B expression in patients with laryngeal squamous cell carcinoma. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,1,1 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23794145&form=6&db=m MicroRNA-212 inhibits proliferation of gastric cancer by directly repressing retinoblastoma binding protein 2. causal interaction,unassigned 2,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23922798&form=6&db=m Histone demethylase retinoblastoma binding protein 2 is overexpressed in hepatocellular carcinoma and negatively regulated by hsa-miR-212. causal interaction,diagnostic usage,unassigned 3,2,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25628922&form=6&db=m KDM5B is overexpressed in gastric cancer and is required for gastric cancer cell proliferation and metastasis. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25686748&form=6&db=m Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism. ongoing research,therapeutic application,unassigned 1,1,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26858085&form=6&db=m Enhancement of Proliferation and Invasion of Gastric Cancer Cell by KDM5C Via Decrease in p53 Expression. causal interaction,diagnostic usage,ongoing research,unassigned 4,1,4,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27874950&form=6&db=m miR-194 inhibits gastric cancer cell proliferation and tumorigenesis by targeting KDM5B. causal interaction,therapeutic application,unassigned 4,1,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30412518&form=6&db=m TRIM15 Exerts Anti-Tumor Effects Through Suppressing Cancer Cell Invasion in Gastric Adenocarcinoma. diagnostic usage,unassigned 4,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30864186&form=6&db=m KDM5D inhibit epithelial-mesenchymal transition of gastric cancer through demethylation in the promoter of Cul4A in male. causal interaction,ongoing research,therapeutic application,unassigned 4,3,1,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31985200&form=6&db=m Extended Recognition of the Histone H3 Tail by Histone Demethylase KDM5A. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,1,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32155529&form=6&db=m Discovery of pyrazole derivatives as cellular active inhibitors of histone lysine specific demethylase 5B (KDM5B/JARID1B). causal interaction,therapeutic application,unassigned 4,4,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32196595&form=6&db=m ETV4 promotes the progression of gastric cancer through regulating KDM5D. causal interaction,diagnostic usage,ongoing research,therapeutic application 2,2,4,1 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32651355&form=6&db=m Long intergenic non-protein-coding RNA 01446 facilitates the proliferation and metastasis of gastric cancer cells through interacting with the histone lysine-specific demethylase LSD1. causal interaction,unassigned 1,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34273914&form=6&db=m Increased Mars2 expression upon microRNA-4661-5p-mediated KDM5D downregulation is correlated with malignant degree of gastric cancer cells. causal interaction,diagnostic usage,therapeutic application,unassigned 4,3,3,0 1.14.11.67 Stomach Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34372882&form=6&db=m ELK4 promotes the development of gastric cancer by inducing M2 polarization of macrophages through regulation of the KDM5A-PJA2-KSR1 axis. unassigned - 1.14.11.67 Stroke http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33712031&form=6&db=m X chromosome escapee genes are involved in ischemic sexual dimorphism through epigenetic modification of inflammatory signals. causal interaction,ongoing research,unassigned 1,2,0 1.14.11.67 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26788140&form=6&db=m siRNA targeting RBP2 inhibits expression, proliferation, tumorigenicity and invasion in thyroid carcinoma cells. ongoing research,unassigned 4,0 1.14.11.67 Thyroid Cancer, Papillary http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34143366&form=6&db=m microRNA-181a promotes the oncogene S100A2 and enhances papillary thyroid carcinoma growth by mediating the expression of histone demethylase KDM5C. ongoing research,unassigned 1,0 1.14.11.67 Tics http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445934&form=6&db=m Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24412361&form=6&db=m The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29968419&form=6&db=m Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy. causal interaction,ongoing research,therapeutic application,unassigned 3,3,4,0 1.14.11.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31776402&form=6&db=m Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,3,3,1 1.14.11.67 Triple Negative Breast Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33145271&form=6&db=m Tumor mutation burden and JARID2 gene alteration are associated with short disease-free survival in locally advanced triple-negative breast cancer. causal interaction,ongoing research,unassigned 4,3,0 1.14.11.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20226085&form=6&db=m Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,4,4,4 1.14.11.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23579952&form=6&db=m Connexin 26 is Down-Regulated by KDM5B in the Progression of Bladder Cancer. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,2,0 1.14.11.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28445934&form=6&db=m Jarid2 is essential for the maintenance of tumor initiating cells in bladder cancer. causal interaction,diagnostic usage,ongoing research,therapeutic application 4,3,4,4 1.14.11.67 Urinary Bladder Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31125562&form=6&db=m Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling. causal interaction,diagnostic usage,ongoing research,therapeutic application 1,3,4,1 1.14.11.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28082020&form=6&db=m miR424-5p functions as an anti-oncogene in cervical cancer cell growth by targeting KDM5B via the Notch signaling pathway. unassigned - 1.14.11.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29339538&form=6&db=m E6 Protein Expressed by High-Risk HPV Activates Super-Enhancers of the diagnostic usage,ongoing research,therapeutic application,unassigned 1,2,1,0 1.14.11.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30132864&form=6&db=m HPV16 E7-induced upregulation of KDM2A promotes cervical cancer progression by regulating miR-132-radixin pathway. causal interaction,diagnostic usage,therapeutic application,unassigned 3,4,4,0 1.14.11.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32918895&form=6&db=m Human papillomavirus type 16 E7 oncoprotein-induced upregulation of lysine-specific demethylase 5A promotes cervical cancer progression by regulating the microRNA-424-5p/suppressor of zeste 12 pathway. causal interaction,diagnostic usage,ongoing research,therapeutic application 3,4,4,4 1.14.11.67 Uterine Cervical Neoplasms http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33117625&form=6&db=m Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways. causal interaction,unassigned 2,0 1.14.11.67 Virus Diseases http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28484864&form=6&db=m Genome-Wide Association Study Identifies Loci Associated with Resistance to Viral Nervous Necrosis Disease in Asian Seabass. causal interaction,unassigned 4,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20181063&form=6&db=m A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C. causal interaction,therapeutic application,unassigned 1,1,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21074441&form=6&db=m Inactive yet indispensable: the tale of Jarid2. causal interaction,unassigned 3,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21220025&form=6&db=m Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly. causal interaction,unassigned 3,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21811233&form=6&db=m Jarid2 regulates mouse epidermal stem cell activation and differentiation. causal interaction,unassigned 4,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24778210&form=6&db=m Histone demethylase KDM5B is a key regulator of genome stability. causal interaction,unassigned 4,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27050510&form=6&db=m H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1. causal interaction,therapeutic application,unassigned 3,1,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28572115&form=6&db=m Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair. causal interaction,therapeutic application,unassigned 2,1,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32208897&form=6&db=m Effect of histone demethylase KDM5A on the odontogenic differentiation of human dental pulp cells. diagnostic usage,therapeutic application,unassigned 1,1,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32868382&form=6&db=m KDM5B is essential for the hyper-activation of PI3K/AKT signaling in prostate tumorigenesis. causal interaction,ongoing research,unassigned 4,2,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34127738&form=6&db=m Y disruption, autosomal hypomethylation and poor male lung cancer survival. causal interaction,diagnostic usage,unassigned 4,4,0 1.14.11.67 [histone h3]-trimethyl-l-lysine4 demethylase deficiency http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34522206&form=6&db=m Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis. causal interaction,ongoing research,therapeutic application,unassigned 4,1,1,0