EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   6.3.2.43 | ATP + [LysW]-C-terminal-L-glutamate + L-2-aminoadipate |
mutant enzyme N264G/T265T shows a substrate preference for glutamate over L-2-aminoadipate contrasting distinctly with the substrate specificity of wild-type enzyme, which shows a distinct preference for L-2-aminoadipate over glutamate |
Sulfolobus acidocaldarius DSM 639 |
ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate |
- |
? |
| 6.3.2.43 | ATP + [LysW]-C-terminal-L-glutamate + L-2-aminoadipate |
- |
Thermococcus kodakarensis |
ADP + phosphate + [LysW]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine |
- |
? |
| 6.3.2.43 | ATP + [LysW]-C-terminal-L-glutamate54 + L-2-aminoadipate |
the enzyme is involved in biosynthesis of lysine. LysX activates the gamma-carboxyl group of the C-terminal Glu54 of the 2-L-aminoaadipate carrier-protein LysW by phosphorylation, with concomitant conversion of ATP to ADP. LysX recognizes not only the C-terminal glutamate residue of LysW but also other portions, possibly the globular domain of LysW specifically |
Thermus thermophilus |
ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54 |
- |
? |
| 6.3.2.43 | ATP + [LysW]-C-terminal-L-glutamate54 + L-2-aminoadipate |
LysX activates the gamma-carboxyl group of the C-terminal Glu54 of the 2-L-aminoaadipate carrier-protein LysW by phosphorylation, with concomitant conversion of ATP to ADP. LysX recognizes not only the C-terminal glutamate residue of LysW but also other portions, possibly the globular domain of LysW specifically |
Thermus thermophilus |
ADP + phosphate + [LysW]-C-terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate54 |
- |
? |
| 6.3.2.43 | more |
purified recombinant TK0278 recognizes alpha-aminoadipate (AAA) and glutamate as substrates and ligated both compounds with TK0279, an amino group carrier protein LysW in this microorganism, in an ATP-dependent manner |
Thermococcus kodakarensis |
? |
- |
- |
| 6.3.2.43 | more |
purified recombinant TK0278 recognizes alpha-aminoadipate (AAA) and glutamate as substrates and ligated both compounds with TK0279, an amino group carrier protein LysW in this microorganism, in an ATP-dependent manner |
Thermococcus kodakarensis JCM 12380 |
? |
- |
- |
| 6.3.2.43 | more |
purified recombinant TK0278 recognizes alpha-aminoadipate (AAA) and glutamate as substrates and ligated both compounds with TK0279, an amino group carrier protein LysW in this microorganism, in an ATP-dependent manner |
Thermococcus kodakarensis ATCC BAA-918 |
? |
- |
- |
