Information on EC 6.3.2.43 - [amino group carrier protein]-L-2-aminoadipate ligase

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IUBMB Comments
The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. This reaction is part of the lysine biosynthesis pathway in these organisms.
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The expected taxonomic range for this enzyme is: Bacteria, Archaea
Synonyms
alpha-aminoadipate-lysW ligase lysX, LysX, More, RimK-related lysine biosynthesis protein, Saci_0754, Tk0278, TkLysX/ArgX, TtLysX, [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate:L-2-aminoadipate ligase (ADP-forming), [lysine-biosynthesis-protein LysW]-L-2-aminoadipate ligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + an [amino group carrier protein]-C-terminal-L-glutamate + L-2-aminoadipate = ADP + phosphate + an [amino group carrier protein]-C-terminal-N-(1,4-dicarboxybutyl)-L-glutamine
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
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