EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.12.2 | more |
TNF-alpha receptor signaling regulates epithelial cell secretion of inflammation and invasion mediators involving signaling through IkappaB kinase complex 2, IKB, nuclear factor kappaB, extracellular signal-regulated kinase, mitogen-activated protein kinase kinase, p38, and phosphatidylinositol 3-kinase, and Akt1/2. MEK, p38, and IKK inhibitors block TNF-alpha-induced IL-8, IL-6, and GM-CSF secretion and 12z invasion, whereas the PI3K inhibitors do not, overview |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | more |
MKK signaling is required for cell proliferation and for cytokine release in vitro |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | more |
substrate binding via the D-domain of the MKK |
Drosophila melanogaster |
? |
- |
? |
| 2.7.12.2 | more |
substrate binding via the D-domain of the MKK |
Rattus norvegicus |
? |
- |
? |
| 2.7.12.2 | more |
substrate binding via the D-domain of the MKK |
Xenopus laevis |
? |
- |
? |
| 2.7.12.2 | more |
substrate binding via the D-domain of the MKK |
Homo sapiens |
? |
- |
? |
| 2.7.12.2 | more |
substrate binding via the D-domain of the MKK |
Mus musculus |
? |
- |
? |
| 2.7.12.2 | more |
GhMKK3 interacts with GhMPK7, a typical C group MAPK member, and GhPIP1 potein. GhMPK7 is phosphorylated by GhMKK3 in protoplasts |
Gossypium hirsutum |
? |
- |
? |
| 2.7.12.2 | more |
MKK4 phosphorylates JNK on Tyr, while MKK7 phosphorylates Thr, and MKK4 and MKK7 together cause dual phosphorylation of JNK thus, optimal activation |
Mus musculus |
? |
- |
? |
| 2.7.12.2 | more |
protein-protein docking of MAPKK and MAPK |
Oryza sativa Indica Group |
? |
- |
? |
