EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   2.7.11.23 | more |
BRD4 autophosphorylation in an in vitro kinase reaction. Phoshorylation site determination with RNA Pol II CTD using a series of GST-CTD fusions with 25- or 16-heptad repeats bearing alanine substitutions in every heptad at Ser2, Ser5, Ser7, or Thr4 as substrates |
Mus musculus |
? |
- |
? |
| 2.7.11.23 | more |
Ctk3 shows no binding to CTD peptides |
Schizosaccharomyces pombe |
? |
- |
? |
| 2.7.11.23 | more |
Drosophila CDK12 manifests CTD kinase activity in vitro |
Drosophila melanogaster |
? |
- |
? |
| 2.7.11.23 | more |
during transcription after repair, UV irradiation induces a specific Ser-2 phosphorylation of the RNA polymerase II and this phosphorylation is Cockayne syndrome group B protein-dependent. The CDK9 subunit of positive transcription elongation factor b is not responsible for this phosphorylation but instead might play a nonenzymatic role in transcription restart after DNA repair |
Homo sapiens |
? |
- |
- |
| 2.7.11.23 | more |
dynamic changes in the CTD phosphorylation pattern due to a complex interplay of various kinases and phosphatases subsequently orchestrate the binding of CTD interacting proteins, cf. CTD code |
Schizosaccharomyces pombe ATCC 24843 |
? |
- |
? |
