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EC Number Substrates Commentary Substrates Organism Products Commentary (Products) Reversibility
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt Canis lupus familiaris ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more the p85alpha subunit of phosphatidylinositol 3-kinase has GTPase-activating protein activity toward Rab5 and Rab4, small monomeric GTPases important in the regulation of RTK endocytosis, trafficking, and degradation pathways Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more a p110alpha/beta-subunit binds to a p85 regulatory subunit, and this heterodimer is recruited to the membrane through the association with phosphotyrosyl proteins, leading to production of phosphatidylinositol 3,4,5-triphosphate, PIP3, followed by activation of downstream signal pathway(s) Rattus norvegicus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more regulatory domain p85 interacts with RAS-GTP Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more the enzyme also catalyzes the reactions of EC 2.7.1.68, 1-phosphatidylinositol-4-phosphate 5-kinase, and EC 2.7.1.67, 1-phosphatidylinositol 4-kinase Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more the single class 1B catalytic isoform p110gamma binds to either p101 or p84/p87 adaptors, which function to potentiate activation by betagamma-subunits of heterotrimeric GTP-binding proteins which facilitate intracellular signalling from G-protein coupled receptors Mus musculus ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more the single class 1B catalytic isoform p110gamma binds to either p101 or p84/p87 adaptors, which function to potentiate activation by betagamma-subunits of heterotrimeric GTP-binding proteins which facilitate intracellular signalling from G-protein coupled receptors Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more phosphoinositide 3-kinase (PI3K) is a dual specificity kinase that is able to phosphorylate both lipid and protein substrates. In addition to their lipid kinase activity, all members of the class 1 PI3K family also possess intrinsic protein kinase activity Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more the enzyme is also active as a serine-dependent protein kinase with Src as substrate and specifically phosphorylating residue Ser70 of Src Homo sapiens ? - ?
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.153more the enzyme is also active as a serine-dependent protein kinase with Src as substrate and specifically phosphorylating residue Ser70 of Src. No activity with S70A Src mutant Homo sapiens ? - ?
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