2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol - Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol - Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol catalyzed by class I and III, and probably by class II enzymes, overview. PI3K is part of the plasma membrane E-cadherin signaling complex Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate - ? 379205 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Gallus gallus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Drosophila melanogaster ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Mammalia ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Dictyostelium discoideum ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Canis lupus familiaris ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Xenopus laevis ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Caenorhabditis elegans ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate p110delta controls a critical checkpoint in peripheral T cell differentiation and clonal expansion Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate PI3Kp110delta is the main source of production of 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate following antigen recognition by B cells, T cells and mast cells Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex Canis lupus familiaris ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate - ? 259674 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate - ? 410732 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate - ? 410732 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate - Mus musculus ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate phosphatidylinositol-3,4,5-triphosphate is a major product of active PI3K, and recruits Akt/PKB to the plasma membrane and the phosphorylation of Akt occurs ? 410732 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate - ? 410732 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate - Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate - ? 378419 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate - Rattus norvegicus ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate - ? 378419 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate - Canis lupus familiaris ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate - ? 378419 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate - Xenopus laevis ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate - ? 378419 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate - ? 378419 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate catalyzed by class I enzyme, overview. PI3K is part of the plasma membrane E-cadherin signaling complex Canis lupus familiaris ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate - ? 378419 2.7.1.153 ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate PIP3 acts as a positive regulator of the Src signaling pathway in Xenopus fertilization Xenopus laevis ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate - ? 378419 2.7.1.153 ATP + Akt - Mus musculus ADP + Akt phosphate - ? 410736 2.7.1.153 ATP + Akt phosphorylation at Ser473 Mus musculus ADP + Akt phosphate - ? 410736 2.7.1.153 ATP + p70S6K - Mus musculus ADP + p70S6K phosphate - ? 410742 2.7.1.153 ATP + phosphatidylinositol - Drosophila melanogaster ADP + phosphatidylinositol 3-phosphate - ? 259676 2.7.1.153 ATP + phosphatidylinositol - Mammalia ADP + phosphatidylinositol 3-phosphate - ? 259676 2.7.1.153 ATP + phosphatidylinositol - Homo sapiens ADP + phosphatidylinositol 3-phosphate - ? 259676 2.7.1.153 ATP + phosphatidylinositol - Dictyostelium discoideum ADP + phosphatidylinositol 3-phosphate - ? 259676 2.7.1.153 ATP + phosphatidylinositol - Caenorhabditis elegans ADP + phosphatidylinositol 3-phosphate - ? 259676 2.7.1.153 ATP + phosphatidylinositol 4-phosphate - Drosophila melanogaster ADP + phosphatidylinositol 4,5-diphosphate - ? 259675 2.7.1.153 ATP + phosphatidylinositol 4-phosphate - Mammalia ADP + phosphatidylinositol 4,5-diphosphate - ? 259675 2.7.1.153 ATP + phosphatidylinositol 4-phosphate - Homo sapiens ADP + phosphatidylinositol 4,5-diphosphate - ? 259675 2.7.1.153 ATP + phosphatidylinositol 4-phosphate - Dictyostelium discoideum ADP + phosphatidylinositol 4,5-diphosphate - ? 259675 2.7.1.153 ATP + phosphatidylinositol 4-phosphate - Caenorhabditis elegans ADP + phosphatidylinositol 4,5-diphosphate - ? 259675 2.7.1.153 ATP + phosphatidylinositol-4,5-bisphosphate - Mus musculus ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.153 ATP + phosphatidylinositol-4,5-bisphosphate - Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.153 ATP + phosphatidylinositol-4,5-bisphosphate - Neopyropia yezoensis ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.153 ATP + phosphatidylinositol-4,5-bisphosphate - Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate i.e. PIP3, PIP3 recruits protein dependent kinase 1, PDK1, and AKT, also known as protein kinase B, PKB, to the plasma membrane ? 378562 2.7.1.153 ATP + phosphatidylinositol-4,5-bisphosphate class I PI3Ks Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.153 ATP + phosphatidylinositol-4,5-bisphosphate class I PI3Ks Homo sapiens ADP + phosphatidylinositol-3,4,5-trisphosphate the product allows for the recruitment to the plasma membrane of proteins containing a pleckstrin homology domain ? 378562 2.7.1.153 ATP + phosphatidylinositol-4,5-bisphosphate - Neopyropia yezoensis TU-1 ADP + phosphatidylinositol-3,4,5-trisphosphate - ? 378562 2.7.1.153 additional information - Homo sapiens ? - ? 89 2.7.1.153 additional information enzyme interacts with active, GTP-bound Ras Mammalia ? - ? 89 2.7.1.153 additional information p110delta does not phosphorylate the p85 adaptor but instead harbors an intrinsic autophosphorylation capacity Homo sapiens ? - ? 89 2.7.1.153 additional information enzyme can promote proliferation Drosophila melanogaster ? - ? 89 2.7.1.153 additional information enzyme can promote proliferation Mammalia ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Drosophila melanogaster ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Mammalia ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Dictyostelium discoideum ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and DNA synthesis Caenorhabditis elegans ? - ? 89 2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Drosophila melanogaster ? - ? 89 2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Mammalia ? - ? 89 2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Dictyostelium discoideum ? - ? 89 2.7.1.153 additional information enzyme is involved in the synthesis of 3-phosphoinositides. Class I phosphoinositide 3-kinases are further subdivided into class IA and IB enzymes, which signal downstream of tyrosine kinase and heterotrimeric G protein-coupled receptors, respectively. All class I phosphoinositide 3-kinase members also bind to Ras, but the role of this interaction in physiological phosphoinositide 3-kinase signalling is not entirely clear Caenorhabditis elegans ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Drosophila melanogaster ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Mammalia ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Dictyostelium discoideum ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase and apoptosis Caenorhabditis elegans ? - ? 89 2.7.1.153 additional information enzyme is activated by binding of osteopontin to integrin alphavbeta3 Gallus gallus ? - ? 89 2.7.1.153 additional information involvement of the enzyme in CD18-mediated adhesion of human neutrophils to fibrinogen Homo sapiens ? - ? 89 2.7.1.153 additional information the adaptor subunits of the class IA enzymes bind phosphorylated Tyr residues, thereby linking the phosphoinositide 3-kinases catalytic subunit to tyr kinase signalling pathways Mammalia ? - ? 89 2.7.1.153 additional information mechanism of signal down-regulation of insulin receptor substrate mediated by monomeric p85 enzyme regulatory subunit Mus musculus ? - ? 89 2.7.1.153 additional information subunit p101 is responsible for phosphatidylinositol-4,5-bisphosphate substrate selectivity of enzyme gamma isoform by sensitizing p110 gamma toward G-protein beta,gamma-subunits in the presence of phosphatidylinositol-4,5-bisphosphate Homo sapiens ? - ? 89 2.7.1.153 additional information p110delta is an important signaling component for efficient axonal elongation in the developing and regenerating nervous system Mus musculus ? - ? 89 2.7.1.153 additional information p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN Mus musculus ? - ? 89 2.7.1.153 additional information PI3K p110delta contributes to cellular and humoral immunity. PI3K p110delta regulates the diffentiation of peripheral helper T-cells towards the Th1 and Th2 lineages. PI3K p110delta is critical to regulatory T-cell development and function Mus musculus ? - ? 89 2.7.1.153 additional information PI3K p110delta play a role in the regulation of RAG gene expression and thereby LC allelic/isotype exclusion Mus musculus ? - ? 89 2.7.1.153 additional information PI3Kgamma plays an important role in neutrophil emigration but not rolling and limited adhesion in postcapillary venules in vivo. The leukocyte but not the endothelial PI3Kgamma is critically involved in the early neutrophil emigration into the inflamed tissues. The delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent Mus musculus ? - ? 89 2.7.1.153 additional information role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation Mus musculus ? - ? 89 2.7.1.153 additional information the delayed neutrophil emigration in response to neutrophil chemokines is independent of the function of PI3Lgamma but is PI3Kdelta dependent Mus musculus ? - ? 89 2.7.1.153 additional information function of class IA phosphatidylinositol 3-kinases in the pre-T-cell receptor-controlled developmental transition of CD4-/CD8- double-negative to CD4+/CD8+ double-positive thymocytes Mus musculus ? - ? 89 2.7.1.153 additional information molecular model for the regulation of PI3K signaling by NCoR, a receptor corepressor and regulator of thyroid receptor-activated PI3K signaling Mus musculus ? - ? 89 2.7.1.153 additional information PI3K generates phosphatidylinositol 3,4,5 trisphosphate Homo sapiens ? - ? 89 2.7.1.153 additional information the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt Homo sapiens ? - ? 89 2.7.1.153 additional information the enzyme is activated and associated to E-cadherin complexes, the assembly is mediated by docking proteins, e.g. beta-catenin, gamma-catenin, and Dlg, and involves c-SRC. Cell-cell adhesion induces c-SRC recruitment and E-cadherin complex assembly as well as activity of PI3K, regulatory and molecular mechanism, overview. PI3K, stimulated by E-cadherin adhesion, activates PKB/Akt Canis lupus familiaris ? - ? 89 2.7.1.153 additional information the p85alpha subunit of phosphatidylinositol 3-kinase has GTPase-activating protein activity toward Rab5 and Rab4, small monomeric GTPases important in the regulation of RTK endocytosis, trafficking, and degradation pathways Homo sapiens ? - ? 89 2.7.1.153 additional information a p110alpha/beta-subunit binds to a p85 regulatory subunit, and this heterodimer is recruited to the membrane through the association with phosphotyrosyl proteins, leading to production of phosphatidylinositol 3,4,5-triphosphate, PIP3, followed by activation of downstream signal pathway(s) Rattus norvegicus ? - ? 89 2.7.1.153 additional information regulatory domain p85 interacts with RAS-GTP Homo sapiens ? - ? 89 2.7.1.153 additional information the enzyme also catalyzes the reactions of EC 2.7.1.68, 1-phosphatidylinositol-4-phosphate 5-kinase, and EC 2.7.1.67, 1-phosphatidylinositol 4-kinase Homo sapiens ? - ? 89 2.7.1.153 additional information the single class 1B catalytic isoform p110gamma binds to either p101 or p84/p87 adaptors, which function to potentiate activation by betagamma-subunits of heterotrimeric GTP-binding proteins which facilitate intracellular signalling from G-protein coupled receptors Mus musculus ? - ? 89 2.7.1.153 additional information the single class 1B catalytic isoform p110gamma binds to either p101 or p84/p87 adaptors, which function to potentiate activation by betagamma-subunits of heterotrimeric GTP-binding proteins which facilitate intracellular signalling from G-protein coupled receptors Homo sapiens ? - ? 89 2.7.1.153 additional information phosphoinositide 3-kinase (PI3K) is a dual specificity kinase that is able to phosphorylate both lipid and protein substrates. In addition to their lipid kinase activity, all members of the class 1 PI3K family also possess intrinsic protein kinase activity Homo sapiens ? - ? 89 2.7.1.153 additional information the enzyme is also active as a serine-dependent protein kinase with Src as substrate and specifically phosphorylating residue Ser70 of Src Homo sapiens ? - ? 89 2.7.1.153 additional information the enzyme is also active as a serine-dependent protein kinase with Src as substrate and specifically phosphorylating residue Ser70 of Src. No activity with S70A Src mutant Homo sapiens ? - ? 89