EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
  1.8.4.11 | alpha-synuclein-L-methionine (S)-S-oxide + thioredoxin |
- |
Bos taurus |
alpha-synuclein-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.11 | alpha1-antitrypsin + thioredoxin disulfide + H2O |
Met358 within alpha1-antitrypsin is oxidized to (S)-methionine sulfoxide |
Mus musculus |
? |
- |
? |
| 1.8.4.11 | apolipoprotein A-I + dithiothreitol |
the myristoylated enzyme reduces the methionine sulfoxides in apolipoprotein A-I four times faster than nonmyristoylated enzyme |
Mus musculus |
? |
- |
? |
| 1.8.4.11 | calmodulin + thioredoxin disulfide + H2O |
Met77 within calmodulin is oxidized to (S)-methionine sulfoxide |
Mus musculus |
? |
- |
r |
| 1.8.4.11 | calmodulin L-methionine-(S)-sulfoxide + thioredoxin |
MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview |
Rattus norvegicus |
calmodulin L-methionine + thioredoxin disulfide |
- |
? |
| 1.8.4.11 | calmodulin L-methionine-(S)-sulfoxide + thioredoxin |
MsrA is specific for the S-form, recombinant human calmodulin, recombinant rat enzyme, artificial system, determination of oxidized methionine residues being reduced by the enzyme, overview |
Rattus norvegicus |
calmodulin L-methionine + thioredoxin disulfide |
- |
? |
| 1.8.4.11 | calmodulin-L-methionine (S)-S-oxide + thioredoxin |
MsrBA is able to completely reduce (i.e., repair) MetSO in the calcium regulatory protein calmodulin. The efficient repair is the coordinate activity of the two catalytic domains in the MsrBA fusion protein, which results in a 1 order of magnitude rate enhancement in comparison to those of the individual MsrA or MsrB enzyme alone |
Shewanella oneidensis |
calmodulin-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.11 | calmodulin-L-methionine (S)-sulfoxide + thioredoxin |
- |
Escherichia coli |
calmodulin-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.11 | dabsyl-L-methionine (R)-sulfoxide + thioredoxin |
- |
Mus musculus |
dabsyl-L-methionine + thioredoxin disulfide + H2O |
- |
? |
| 1.8.4.11 | dabsyl-L-methionine (S)-S-oxide + dithiothreitol |
- |
Treponema denticola |
dabsyl-L-methionine + dithiothreitol disulfide + H2O |
- |
? |
