EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
    1.1.99.2 | L-2-hydroxyglutarate + NAD+ |
- |
Homo sapiens |
2-oxoglutarate + NADH + H+ |
- |
r |
| 1.1.99.2 | L-2-hydroxyglutarate + NAD+ |
- |
Rattus norvegicus |
2-oxoglutarate + NADH + H+ |
- |
? |
| 1.1.99.2 | more |
high levels of the enzyme is produced at the late stage of cultivation in the presence of citrate and with limited aeration |
Alcaligenes sp. |
? |
- |
? |
| 1.1.99.2 | more |
no activity with D-2-hydroxyglutarate, L-malate, and L-lactate |
Rattus norvegicus |
? |
- |
? |
| 1.1.99.2 | more |
mutations (K81E, E176D, DELTA-exon9) found in patients with L-2-hydroxyglutaric aciduria supress L-2-hydroxyglutarate dehydrogenase activity. L-2-hydroxyglutartic aciduria is due to a deficiency in L-2-hydroxyglutarate dehydrogenase |
Homo sapiens |
? |
- |
? |
| 1.1.99.2 | more |
the enzyme is not active in the presence of NAD+, NADP+, cytochrome c or O2, as well as glycolate, D-lactate and L-lactate |
Arabidopsis thaliana |
? |
- |
? |
| 1.1.99.2 | more |
no activity with 3-acetylpyridine adenine dinucleotide or NADP+ |
Homo sapiens |
? |
- |
? |
| 1.1.99.2 | more |
no activity with 3-acetylpyridine adenine dinucleotide or NADP+ |
Rattus norvegicus |
? |
- |
? |
