1.1.99.2	(R)-2-hydroxyglutarate + 2,6-dichlorophenolindophenol	3.7% activity compared to (S)-2-hydroxyglutarate	Arabidopsis thaliana	2-oxoglutarate + reduced 2,6-dichlorophenolindophenol	-	?	438555	
1.1.99.2	(R)-2-hydroxyglutarate + NAD+	about 10% of the activity with (S)-2-hydroxyglutarate	Alcaligenes sp.	2-oxoglutarate + NADH	-	ir	257807	
1.1.99.2	(S)-2-hydroxyglutarate + 2,6-dichlorophenolindophenol	-	Arabidopsis thaliana	2-oxoglutarate + reduced 2,6-dichlorophenolindophenol	-	?	438589	
1.1.99.2	(S)-2-hydroxyglutarate + acceptor	-	Homo sapiens	2-oxoglutarate + reduced acceptor	-	?	370751	
1.1.99.2	(S)-2-hydroxyglutarate + acceptor	-	Rattus norvegicus	2-oxoglutarate + reduced acceptor	-	?	370751	
1.1.99.2	(S)-2-hydroxyglutarate + acceptor	enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria	Rattus norvegicus	2-oxoglutarate + reduced acceptor	-	?	370751	
1.1.99.2	(S)-2-hydroxyglutarate + acceptor	enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria	Homo sapiens	2-oxoglutarate + reduced acceptor	-	?	370751	
1.1.99.2	(S)-2-hydroxyglutarate + FAD	-	Rattus norvegicus	2-oxoglutarate + FADH2	-	?	370752	
1.1.99.2	(S)-2-hydroxyglutarate + FAD	enzyme deficiency might be the cause of L-2-hydroxyglutaric aciduria	Rattus norvegicus	2-oxoglutarate + FADH2	-	?	370752	
1.1.99.2	(S)-2-hydroxyglutarate + iodonitrotetrazolium	-	Rattus norvegicus	2-oxoglutarate + ?	-	?	371407	
1.1.99.2	(S)-2-hydroxyglutarate + NAD+	-	Homo sapiens	2-oxoglutarate + NADH + H+	-	?	188093	
1.1.99.2	(S)-2-hydroxyglutarate + NAD+	-	Rattus norvegicus	2-oxoglutarate + NADH + H+	-	?	188093	
1.1.99.2	(S)-2-hydroxyglutarate + NAD+	in the reverse reaction almost 100% production of the S-isomer of 2-hydroxyglutarate	Alcaligenes sp.	2-oxoglutarate + NADH + H+	-	r	188093	
1.1.99.2	2-hydroxy-n-hexanoate + NAD+	at 12.4% of the activity with 2-oxoglutarate	Alcaligenes sp.	2-oxo-n-hexanoate + NADH + H+	-	?	257810	
1.1.99.2	2-hydroxy-n-pentanoate + NAD+	at 10.7% of the activity with 2-oxoglutarate	Alcaligenes sp.	2-oxo-n-pentanoate + NADH + H+	-	?	257809	
1.1.99.2	2-hydroxybutanoate + NAD+	at 9.6% of the activity with 2-oxoglutarate	Alcaligenes sp.	2-oxobutanoate + NADH	-	?	257808	
1.1.99.2	2-hydroxymalonate + NAD+	at 29.3% of the activity with 2-oxoglutarate	Alcaligenes sp.	oxomalonate + NADH + H+	-	?	257811	
1.1.99.2	L-2-hydroxyglutarate + FAD	-	Homo sapiens	2-oxoglutarate + FADH2	-	ir	448726	
1.1.99.2	L-2-hydroxyglutarate + iodonitrotetrazolium chloride	activity assay	Homo sapiens	2-oxoglutarate + reduced iodonitrotetrazolium chloride	-	?	405534	
1.1.99.2	L-2-hydroxyglutarate + NAD+	-	Homo sapiens	2-oxoglutarate + NADH + H+	-	?	448727	
1.1.99.2	L-2-hydroxyglutarate + NAD+	-	Homo sapiens	2-oxoglutarate + NADH + H+	-	r	448727	
1.1.99.2	L-2-hydroxyglutarate + NAD+	-	Rattus norvegicus	2-oxoglutarate + NADH + H+	-	?	448727	
1.1.99.2	additional information	high levels of the enzyme is produced at the late stage of cultivation in the presence of citrate and with limited aeration	Alcaligenes sp.	?	-	?	89	
1.1.99.2	additional information	no activity with D-2-hydroxyglutarate, L-malate, and L-lactate	Rattus norvegicus	?	-	?	89	
1.1.99.2	additional information	mutations (K81E, E176D, DELTA-exon9) found in patients with L-2-hydroxyglutaric aciduria supress L-2-hydroxyglutarate dehydrogenase activity. L-2-hydroxyglutartic aciduria is due to a deficiency in L-2-hydroxyglutarate dehydrogenase	Homo sapiens	?	-	?	89	
1.1.99.2	additional information	the enzyme is not active in the presence of NAD+, NADP+, cytochrome c or O2, as well as glycolate, D-lactate and L-lactate	Arabidopsis thaliana	?	-	?	89	
1.1.99.2	additional information	no activity with 3-acetylpyridine adenine dinucleotide or NADP+	Homo sapiens	?	-	?	89	
1.1.99.2	additional information	no activity with 3-acetylpyridine adenine dinucleotide or NADP+	Rattus norvegicus	?	-	?	89