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EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Commentary Reference
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - - 648562, 648563, 648565
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - 0.3 microU/mg protein 664165
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - 1.4 mU/mg in brain determined with the ONPG-assay with the o-nitrophenyl-beta-D-glactopyranoside substrate of a mouse heterozygous for the Pts-lacZ allele (encoding a fusion protein of N-terminal 35 amino acids of 6-pyruvoyl-tetrahydropterin synthase and beta-galactosidase), 1 U is defined as 1 OD at 420 nm per minute at pH 7.5 and 37°C 664165
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - 10fold more Flag-tag fused PTPS per total protein in cytoplasm compared to nucleus, no activity of Flag-tag fused PTPS in the nucleus 664165
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - 18 microU/mg total protein 664165
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - 2.2 mU/mg in liver determined with the ONPG-assay with the o-nitrophenyl-beta-D-glactopyranoside substrate of a mouse heterozygous for the Pts-lacZ allele (encoding a fusion protein of N-terminal 35 amino acids of 6-pyruvoyl-tetrahydropterin synthase and beta-galactosidase), 1 U is defined as 1 OD at 420 nm per minute at pH 7.5 and 37°C 664165
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - 3.5 mU/mg in liver determined with the ONPG-assay with the o-nitrophenyl-beta-D-glactopyranoside substrate of a mouse homozygous for the Pts-lacZ allele (encoding a fusion protein of N-terminal 35 amino acids of 6-pyruvoyl-tetrahydropterin synthase and beta-galactosidase), 1 U is defined as 1 OD at 420 nm per minute at pH 7.5 and 37°C 664165
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - 5.3 pmol/min/10*10 platelets, PTPS activity does not change significantly after treatment with glucocorticoids in a dose equivalent to at least 100 mg prednisone for at least 7 days, enzyme assays at 37°C 664613
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - in cells treated with mixed inflammatory cytokines IFNgamma, TNFalpha and IL-1, PTPS messenger RNA abundance and enzyme activity are 10fold and 3fold higher than in untreated cells, respectively 648573
Show all pathways known for 4.2.3.12Display the word mapDisplay the reaction diagram Show all sequences 4.2.3.12-999 - no enzymatic activity detected 690275
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