Literature summary for 4.2.3.12 extracted from

Linscheid, P.; Schaffner, A.; Blau, N.; Schoedon, G.
Regulation of 6-pyruvoyltetrahydropterin synthase activity and messenger RNA abundance in human vascular endothelial cells (1998), Circulation, 98, 1703-1706.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin	Homo sapiens	the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway	6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q03393	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
umbilical vein endothelium	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	in cells treated with mixed inflammatory cytokines IFNgamma, TNFalpha and IL-1, PTPS messenger RNA abundance and enzyme activity are 10fold and 3fold higher than in untreated cells, respectively	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin	-	Homo sapiens	6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate	-	?
6-(L-erythro-1,2-dihydroxypropyl 3-triphosphate)-7,8-dihydropterin	the enzyme catalyzes the second step in the tetrahydrobiopterin biosynthetic pathway	Homo sapiens	6-(1,2-dioxopropyl)-5,6,7,8-tetrahydropterin + triphosphate	-	?

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Release 2023.1 (January 2023)