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Information on EC 4.2.3.12 - 6-pyruvoyltetrahydropterin synthase

for references in articles please use BRENDA:EC4.2.3.12

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IUBMB Comments

Catalyses triphosphate elimination and an intramolecular redox reaction in the presence of Mg2+. It has been identified in human liver. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 3.5.4.16 (GTP cyclohydrolase I) .

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

Synonyms
ptps, 6-pyruvoyl-tetrahydropterin synthase, 6-pyruvoyltetrahydropterin synthase, ptp synthase, ptps-iii, eptps, pyruvoyltetrahydropterin synthase, sco 6650, 6-pyruvoyl tetrahydrobiopterin synthase, ptps homologue, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
drosopterin and aurodrosopterin biosynthesis, erythro-tetrahydrobiopterin biosynthesis I, threo-tetrahydrobiopterin biosynthesis