EC Number   |
General Information |
Reference  |
|---|
    5.3.99.2 | physiological function |
L-PGDS may fine-tune the all-trans retinoic acid signaling in melanocytes |
704365 |
| 5.3.99.2 | physiological function |
lipocalin type prostaglandin D synthase is a multi-functional protein acting as a somnogen (PGD2)-producing enzyme, an extracellular transporter of various lipophilic ligands, and an amyloid-beta chaperone in human cerebrospinal fluid |
704523 |
| 5.3.99.2 | physiological function |
lipocalin-type prostaglandin D synthase acts as both a PGD2 synthase and an extracellular transporter for small lipophilic molecules |
705407 |
| 5.3.99.2 | malfunction |
dextran sodium sulfate treatment to L-PGDS-deficientmice shows lower ulcerative colitis disease activity than control mice |
713720 |
| 5.3.99.2 | malfunction |
the stable transfection with antisense L-PGDS induces markedly the stimulation of fat storage in cultured adipocytes during the maturation phase |
714066 |
| 5.3.99.2 | physiological function |
H-PGDS plays a critical role in the development of allergic rhinitis, especially in the induction of late phase nasal obstruction |
714915 |
| 5.3.99.2 | malfunction |
co-localization of arrestin-3 with L-PGDS is drastically reduced in MG-63 cells when L-PGDS activity is inhibited |
715626 |
| 5.3.99.2 | evolution |
the enzyme is a member of the lipocalin superfamily |
726906 |
| 5.3.99.2 | more |
structure homology modelling using the solution structure of the C65A mouse L-PGDS, PDB code 2RQ0, as template, overview |
726906 |
| 5.3.99.2 | physiological function |
the enzyme shows a protective effect on H2O2-induced apoptosis in neuroblastoma cell line SH-SY5Y, the enzyme level is highly associated with H2O2-induced apoptosis. It protects against neuronal cell death by scavenging reactive oxygen species without losing its ligand-binding function. H2O2 reacts with the thiol of Cys65 of the enzyme |
726906 |
