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Literature summary for 5.3.99.2 extracted from

  • Miyamoto, Y.; Nishimura, S.; Inoue, K.; Shimamoto, S.; Yoshida, T.; Fukuhara, A.; Yamada, M.; Urade, Y.; Yagi, N.; Ohkubo, T.; Inui, T.
    Structural analysis of lipocalin-type prostaglandin D synthase complexed with biliverdin by small-angle X-ray scattering and multi-dimensional NMR (2010), J. Struct. Biol., 169, 209-218.
    View publication on PubMed
Search for more literature for 5.3.99.2

Cloned(Commentary)

Cloned (Comment) Organism
for expression in Escherichia coli BL21DE3 cells Mus musculus

Protein Variants

Protein Variants Comment Organism
DELTA1-24_C65A L-PGDS mutant, preserves a disulfide bond between Cys89 and Cys186 Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
 L-PGDS Mus musculus
21000
-
 L-PGDS bound to biliverdin Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Prostaglandin H2 Mus musculus
-
 Prostaglandin D2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus O09114
-
-

Purification (Commentary)

Purification (Comment) Organism
the DELTA1-24_C65A L-PGDS mutant is purified on a glutathione-Sepharose 4B column and incubated with thrombin to release the L-PGDS, the protein is further purified by gel filtration Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prostaglandin H2
-
 Mus musculus Prostaglandin D2
-
 ?

Synonyms

Synonyms Comment Organism
L-PGDS
-
 Mus musculus
lipocalin-type PGD synthase
-
 Mus musculus
lipocalin-type prostaglandin d synthase
-
 Mus musculus
Prostaglandin-H2 D-isomerase
-
 Mus musculus

General Information

General Information Comment Organism
physiological function lipocalin-type prostaglandin D synthase acts as both a PGD2 synthase and an extracellular transporter for small lipophilic molecules Mus musculus