EC Number   |
General Information |
Reference |
|---|
   5.3.3.12 | malfunction |
a tautomerase-null protein shows reduced binding affinity to the receptors CD74 and CXCR2, and an impaired ability to induce ERK1/2 MAP kinase activation. Cells expressing the tautomerase-null protein show reduced proliferative capacity, and enzyme-deficient mice show a reduced development in benzo[a]pyrene-induced skin tumors. |
727347 |
| 5.3.3.12 | malfunction |
Dct inactivation elevates the level of ROS, increases the numbers of sunburn cells and apoptotic cells, and decreases the amount of eumelanin in the epidermis upon exposure to chronic UVA radiation |
-, 703809 |
| 5.3.3.12 | malfunction |
Dct inactivation in knockout mice exposed to UVA radiation elevates the level of reactive oxygen species, increases the number of sunburn cells and apoptotic cells and decreases the amount of eumelanin in the epidermis |
716471 |
| 5.3.3.12 | malfunction |
enzyme knockdown inhibits ERK1/2 and AKT phosphorylation, increases p53 expression and attenuates proliferation and invasion of PANC-1 cells |
747965 |
| 5.3.3.12 | malfunction |
MIF expression contributes to cell proliferation, invasiveness and neo-angiogenesis of neuroblastoma, gastric, hepatocellular, bladder, and breast carcinomas. MIF takes part in the pathogenesis of Alzheimer's disease and multiple sklerosis |
703331 |
| 5.3.3.12 | malfunction |
MIF is implicated in the pathogenesis of several inflammatory and autoimmune diseases |
702357 |
| 5.3.3.12 | physiological function |
Dct is a critical enzyme in the melanogenesis pathway. It is involved in regulation of DHICA-mediated antioxidation and protection of the skin against UVA radiation |
-, 703809 |
| 5.3.3.12 | physiological function |
DCT plays a critical role in lowering the oxidative stress resulting from melanogenesis |
706613 |
| 5.3.3.12 | physiological function |
Dct plays a role in the regulation of eumelanin antioxidant properties |
716471 |
| 5.3.3.12 | physiological function |
increase in D-dopachrome tautomerase is a response to liver damage, accelerates melanin biosynthesis and protects the liver from oxidative stress induced by CCl4, overview |
695207 |
