EC Number   |
General Information |
Reference |
|---|
   4.6.1.2 | malfunction |
guanyl cyclase-C-knockout mice exhibit hyperactivity and attention deficits |
716928 |
| 4.6.1.2 | malfunction |
guanylyl cyclase-A-deficient mice show cardiac hypertrophy |
708337 |
| 4.6.1.2 | malfunction |
inhibition of soluble guanylyl cyclase reduces vascular endothelial growth factor-induced angiogenesis and permeability |
707075 |
| 4.6.1.2 | physiological function |
activation of sGC is involved in the nitric oxide-induced increases in outflow facility of the eye |
692704 |
| 4.6.1.2 | physiological function |
endoplasmic reticulum-mediated glycosylation is required for the formation of an active catalytic domain, and mutations that inhibit this process cause dwarfism |
748208 |
| 4.6.1.2 | physiological function |
guanyl cyclase-C activation potentiates the excitatory responses mediated by glutamate and acetylcholine receptors via the activity of GMP-dependent protein kinase |
716928 |
| 4.6.1.2 | physiological function |
guanylate cyclase plays a role in migration of A-549 cells |
694121 |
| 4.6.1.2 | physiological function |
guanylyl cyclase-A inhibits angiotensin II type 2 receptor-mediated pro-hypertrophic signaling in the heart |
708337 |
| 4.6.1.2 | physiological function |
in the presence of activators BAY 58-2667 (cinaciguat) and BAY 60-2770, protein levels of isoforms alpha1/beta1 and alpha2/beta1 overexpressed in Sf9 cells decrease. The activator drugs stably insert into the enzyme during protein biosynthesis independent of the heme redox state |
747037 |
| 4.6.1.2 | physiological function |
isozyme RetGC1 is absolutely required for cone function and survival |
714257 |
