EC Number |
General Information |
Reference |
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4.2.1.76 | evolution |
phylogenetic analysis indicates that ATCV-1 has probably acquired its UGD gene via a recent horizontal gene transfer from a green algal host, while an earlier event involving the complete pathway probably occurred between a protozoan ancestor and mimivirus. Chloroviruses, and maybe mimivirus, may encode most, if not all, of the glycosylation machinery involved in the synthesis of specific glycan structures essential for virus replication and infection |
716065 |
4.2.1.76 | evolution |
phylogenetic analysis indicates that ATCV-1 has probably acquired its UGD gene via a recent horizontal gene transfer from a green algal host, while an earlier event involving the complete pathway probably occurred between a protozoan ancestor and mimivirus. While ATCV-1 lacks an epimerase/reductase gene, its Chlorella host may encode this enzyme. Chloroviruses, and maybe mimivirus, may encode most, if not all, of the glycosylation machinery involved in the synthesis of specific glycan structures essential for virus replication and infection |
716065 |
4.2.1.76 | malfunction |
inactivation of GAL102-encoded UDP-glucose 4,6-dehydratase activity causes altered mannosylation of cell wall proteins, loss of cell wall integrity and changes in biofilm characteristics. The reduced virulence of gal102-deficient Candida albicans is associated with ist inability to elicit a strong pro-inflammatory response |
730794 |
4.2.1.76 | physiological function |
UDP-glucose 4, 6-dehydratase activity plays an important role in maintaining cell wall integrity and virulence of Candida albicans |
730794 |