Literature summary for 4.2.1.76 extracted from

Sen, M.; Shah, B.; Rakshit, S.; Singh, V.; Padmanabhan, B.; Ponnusamy, M.; Pari, K.; Vishwakarma, R.; Nandi, D.; Sadhale, P.P.
UDP-glucose 4, 6-dehydratase activity plays an important role in maintaining cell wall integrity and virulence of Candida albicans (2011), PLoS Pathog., 7, e1002384.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UDP-glucose	Candida albicans	-	UDP-4-dehydro-6-deoxy-D-glucose + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UDP-glucose	-	Candida albicans	UDP-4-dehydro-6-deoxy-D-glucose + H2O	-	?

Synonyms

Synonyms	Comment	Organism
GAL102	-	Candida albicans

General Information

General Information	Comment	Organism
malfunction	inactivation of GAL102-encoded UDP-glucose 4,6-dehydratase activity causes altered mannosylation of cell wall proteins, loss of cell wall integrity and changes in biofilm characteristics. The reduced virulence of gal102-deficient Candida albicans is associated with ist inability to elicit a strong pro-inflammatory response	Candida albicans
physiological function	UDP-glucose 4, 6-dehydratase activity plays an important role in maintaining cell wall integrity and virulence of Candida albicans	Candida albicans

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Release 2023.1 (January 2023)