EC Number   |
General Information |
Reference |
|---|
   3.4.24.B3 | malfunction |
MMP11-deficient mice develop higher numbers of metastases than wild-type mice |
-, 708766 |
| 3.4.24.B3 | malfunction |
overexpression of MMP-11 correlates with patients having poorly differentiated tumors and lymph node metastasis. A synergistic effect between MMP-11 and cytoskeleton-20 on risk elevation is significant in patients with advanced tumor stage and lymph node metastasis |
708173 |
| 3.4.24.B3 | malfunction |
role of MMP11 in cancer progression, MMP11 expression correlates with aggressive profile and invasiveness of different types of carcinoma |
-, 708156 |
| 3.4.24.B3 | malfunction |
stromelysin-3 plays a key role in human tumor progression and poor clinical outcome, increased matrix metalloproteinase 11 expression levels are associated with advanced-stage and high-grade tumors, overview |
708668 |
| 3.4.24.B3 | malfunction |
the levels of proliferation and migration of cells transfected with MMP-11 siRNA are significantly reduced, while the levels in MMP-11-plasmid-transfected cells are increased. Variations in intracellular MMP-11 significantly alters the amount of phospho-p65 in thyroid cells, while p65 knockdown does not affect MMP-11 expression |
754241 |
| 3.4.24.B3 | metabolism |
effects of MMP-11 expression on regulation of focal adhesion kinase/Src kinase (FAK/Src) and MAP-Kinase signalling pathway, overview |
754962 |
| 3.4.24.B3 | metabolism |
MMP-11 regulatory migration is associated with the NF-kappaB p65 signaling pathway |
754241 |
| 3.4.24.B3 | more |
the 5-year survival rates of patients with high expression of both MMP-11 and IGF-1 is significantly lower compared to the patients with low expression levels of both MMP-11 and IGF-1 |
753930 |
| 3.4.24.B3 | physiological function |
enzyme MMP-11 is involved in breast cancer initiation, progress and metastases development, MMP-11 plays a key role in the progression of cancer |
752463 |
| 3.4.24.B3 | physiological function |
matrix metalloproteinases (MMPs) are a group of zinc-dependent endopeptidases that digest the intercellular matrix, thereby affecting the tumor microenvironment by promoting angiogenesis, tumor growth, and metastasis. Role of MMP-11 in the mediation of thyroid cancer cell development, as well as in regulation of thyroid cell proliferation and migration. MMP-11 is the most differentially expressed matrix metalloproteinase, MMP. The change in cyclin D1 is consistent with MMP-11 expression, which may explain the changes in proliferation. MMP-11 is located upstream of p65 and regulates its activity. MMP-11 regulatory migration is also associated with the NF-kappaB p65 signaling pathway. MMP-11 promotes activation of p65 |
754241 |
