Literature summary for 3.4.24.B3 extracted from

Zhang, X.; Huang, S.; Guo, J.; Zhou, L.; You, L.; Zhang, T.; Zhao, Y.
Insights into the distinct roles of MMP-11 in tumor biology and future therapeutics (Review) (2016), Int. J. Oncol., 48, 1783-1793 .

Search for more literature for 3.4.24.B3

Application

Application	Comment	Organism
diagnostics	MMP-11 may work as a significant tumor biomarker for early detection of cancer, tumor staging, prognostic analysis, monitoring recurrence during follow-up and also a potential target for immunotherapy against cancer. Prognostic significance of MMP-11 expression in gastric carcinoma. The 5-year survival rates of patients with high expression of both MMP-11 and IGF-1 is significantly lower compared to the patients with low expression levels of both MMP-11 and IGF-1. Expression of MMP-11 and VEGF-C in colorectal adenocarcinoma is believed to be an important index for predicting distant metastases and clinical stages. MMP-11 is not only correlated with advanced-stage and high-grade tumors, but significantly associated with metastasis, especially for lymph node metastasis rather than peritoneal seeding and distant organ metastasis. The expression levels of MMP-11 can be used to identify patients at greater risk for cancer recurrence in breast carcinoma, pancreatic tumors, and colon cancer	Homo sapiens
medicine	enzyme MMP-11 is an antigen target for immunotherapy	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
extracellular	the enzyme is secreted	Homo sapiens	-	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	a zinc-dependent endopeptidase	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P24347	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
breast cancer cell	-	Homo sapiens	-
carcinoma cell	enzyme MMP-11 is expressed exclusively in most primary solid cancer tissues and metastatic lesions	Homo sapiens	-
colorectal adenocarcinoma cell	-	Homo sapiens	-
gastric adenocarcinoma cell	-	Homo sapiens	-
additional information	overexpression of MMP-11 is reported to be associated with several clinicopathological characteristics, such as poor differentiation, lymph node metastasis and lack of progesterone receptor, in oral squamous cell carcinoma as well as in breast carcinoma. MMP-11 has been initially considered expressed in tumor stroma by fibroblasts surrounding tumor cells instead of by tumor cells themselves	Homo sapiens	-
oral squamous cell carcinoma cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
MMP-11	-	Homo sapiens

General Information

General Information	Comment	Organism
additional information	the 5-year survival rates of patients with high expression of both MMP-11 and IGF-1 is significantly lower compared to the patients with low expression levels of both MMP-11 and IGF-1	Homo sapiens
physiological function	MMP-11, which is a secreted protein, not only takes effect in the cytoplasm, but is secreted to the extracellular space as an important component in the microenvironment, affecting both the tumors and the extracellular matrix. Role of MMP-11 in tumorigenesis and cancer progression is regarded as a tumor-facilitating factor by promoting colony formation, remodeling extracellular matrix and suppressing apoptosis. Importance of MMP-11 in modifying tumor microenvironment and potent antitumoral effects on solid tumors. The enzyme degrades proteins of the extracellular matrix. MMP-11 may work as a tumor repressor by inhibiting metastasis in certain tumors. MMP-11 is not only correlated with advanced-stage and high-grade tumors, but significantly associated with metastasis, especially for lymph node metastasis rather than peritoneal seeding and distant organ metastasis	Homo sapiens

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Release 2023.1 (January 2023)