EC Number   |
General Information |
Reference |
|---|
   3.4.21.6 | malfunction |
enzyme inhibition by anticoagulants are recommended for numerous medical conditions, including the prevention and treatment of venous thromboembolism, stroke prevention in patients with atrial fibrillation, and secondary prevention in acute coronary syndromes |
707903 |
| 3.4.21.6 | malfunction |
enzyme inhibition is beneficial in prevention and treatment of thromboembolic disorders |
707025 |
| 3.4.21.6 | malfunction |
enzyme inhibition reduces thioacetamide-induced murine liver fibrosis |
753093 |
| 3.4.21.6 | malfunction |
factor Xa deficiency is a rare inherited autosomal recessive trait, a patient harboring the mutation is affected by a severe bleeding diathesis |
710601 |
| 3.4.21.6 | metabolism |
constituents of platelet membranes regulate the activity of the prothrombinase complex. Membranes containing phosphatidylcholine and phosphatidylethanolamine bind factor Va with high affinity in the absence of phosphatidylserine, specific protein-PE interactions appear to contribute to the effects of phosphatidylethanolamine |
717848 |
| 3.4.21.6 | metabolism |
the enzyme is involved in the blood coagulation cascade, overview |
708451 |
| 3.4.21.6 | more |
factor Va is the non-enzymatic cofactor of prothrombinase, which comprises, along with FVa, the enzyme factor Xa, a negatively charged phospholipid surface, and calcium ions |
718415 |
| 3.4.21.6 | more |
prothrombin specifically active site-labeled with D-Phe-Pro-Arg-CH2Cl shows altered activity in vitro and in vivo compared to the wild-type protein, overview |
717829 |
| 3.4.21.6 | more |
prothrombin specifically active site-labeled with D-Phe-Pro-Arg-CH2Cl shows altered activity in vitro and in vivo compared to the wild-type protein. [AF660]FPR-mouse ProT binds to fibroblast membranes in mouse plasma, overview |
717829 |
| 3.4.21.6 | more |
the enzyme is similar to human coagulation factor X |
731389 |
