EC Number   |
General Information |
Reference |
|---|
    3.1.3.5 | malfunction |
cytosolic 5'-nucleotidase cN-II is implicated in drug resistance in patients and dephosphorylates 5-fluoro-dUMP, 3'-azido-3-dTMP, 2'-chloro-2'-deoxyAMP, and related compounds, which represent the monophosphorylated forms of nucleoside prodrugs |
716355 |
| 3.1.3.5 | malfunction |
enzyme deficient mice exhibit decreased callus size after intramembranous bone repair and reduced alkaline phosphatase activity during intramembranous bone healing. Enzyme deficiency leads to decreased osteoclast activity during the remodeling phase of intramembranous bone healing |
752292 |
| 3.1.3.5 | malfunction |
enzyme knockdown enhances tumor necrosis factor-stimulated interleukin-8 production |
752251 |
| 3.1.3.5 | malfunction |
the knockdown of enzyme expression in cultured intestinal epithelial cells results in dramatic defects in intraepithelial localization and replication as well as defective transepithelial translocation by Salmonella spp. |
750738 |
| 3.1.3.5 | metabolism |
5'-nucleotidases are involved in the purine and pyrimidine nucleotide metabolic pathways, overview. CD73 enzymatic activity is implicated in two major extracellular metabolic pathways with distinct physiological roles, extracellular adenosine nucleotide and NAD+ metabolism |
716355 |
| 3.1.3.5 | metabolism |
the key and rate-limiting enzyme in the ectonucleotidase pathway is ecto-5'-nucleotidase, which catalyzes the final step of dephosphorylation of AMP to adenosine |
-, 715987 |
| 3.1.3.5 | metabolism |
the nucleotide salvage pathway is regulated at a molecular level |
715932 |
| 3.1.3.5 | metabolism |
Trichomonas foetus is devoid of the ability to synthesize purine nucleotides de novo, depending instead on salvaging purines from the host environment. Ecto-5'-nucleotidase catalyzes the final step of extracellular nucleotide degradation, the hydrolysis of nucleoside 5'-monophosphates to the corresponding nucleosides and phosphate |
716985 |
| 3.1.3.5 | more |
CD73 is highly induced by ischemia and hypoxia, and increased expression in cardiac ischemia is mediated by a positive feedback loop involving adenosine |
716355 |
| 3.1.3.5 | more |
the enzyme interferes with the phosphorylation-dependent activation of nucleoside analogues used in the treatment of cancer and viral diseases |
715932 |
