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Literature summary for 3.1.3.5 extracted from

  • Al-Haj, L.; Khabar, K.S.A.
    The intracellular pyrimidine 5'-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling (2018), Sci. Signal., 11, eaal2434 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a 5'-ribonucleotide + H2O Homo sapiens
-
a ribonucleoside + phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
2fTGH cell
-
Homo sapiens
-
A-549 cell
-
Homo sapiens
-
DAUDI cell
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
HEK-293 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
HT-1080 cell
-
Homo sapiens
-
Huh-7 cell
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-
umbilical vein endothelial cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a 5'-ribonucleotide + H2O
-
Homo sapiens a ribonucleoside + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 38000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
NT5C3A
-
Homo sapiens
PN-1
-
Homo sapiens
pyrimidine 5'-nucleotidase
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown enhances tumor necrosis factor-stimulated interleukin-8 production Homo sapiens
physiological function enzyme overexpression increases the abundance of NAD+ and the activation of the sirtuins SIRT1 and SIRT6 Homo sapiens