EC Number   |
General Information |
Reference |
|---|
   3.1.26.11 | evolution |
Trz1 is organized into two beta-lactamase domains connected by a long linker. The N-terminal domain has lost its catalytic residues, but retains the long flexible arm that is important for tRNA binding, while it is the other way around in the C-terminal domain. Trz1 likely evolved from a duplication and fusion of the gene encoding the monomeric short form RNase Z |
751742 |
| 3.1.26.11 | malfunction |
deletion of the chloroplastic TrZS2 gene results in an embryo-lethal phenotype |
710310 |
| 3.1.26.11 | malfunction |
disruption of TRZ2 is responsible for a mutant albino phenotype with deficient chlorophyll content |
730149 |
| 3.1.26.11 | malfunction |
ELAC2 lacking a putative mitochondrial targeting signal (aa 1-30), but not ELAC2 lacking a putative nuclear localization signal (aa 28-35) can increase suppression of ade6-704 in strain yYH1 |
707432 |
| 3.1.26.11 | malfunction |
enzyme inactivation compromises nuclear and mitochondrial tRNA 3'-end processing |
-, 730021 |
| 3.1.26.11 | malfunction |
in a mutant strain, the chromosomal tRNase Z gene is put under control of an IPTG-dependent promoter. Removal of IPTG from the culture medium results in complete growth inhibition, tRNase Z is essential for the organism. Downregulation of Trz expression leads to an accumulation of CCA-less pre-tRNAs in vivo |
710450 |
| 3.1.26.11 | malfunction |
RNZED24 knockout mutation causes early larval lethality. RNaseZ knockout completely blocks tRNA maturation without diminishing the abundance of mature tRNA molecules, affects the nuclear-cytoplasmic distribution of tRNA, decreases cell proliferation but not cell survival, and affects maginal disc growth autonomously |
729616 |
| 3.1.26.11 | malfunction |
silencing of the gene MRPP1 encoding a subunit of the enzyme leads to inhibition of both 5' and 3' processing |
716895 |
| 3.1.26.11 | malfunction |
strains with simultanoeus deletion of genes from RNases II, Z, D, T and PH are not viable, but cells survive when only one of these genes is active |
710450 |
| 3.1.26.11 | malfunction |
The knockout TrZL1 mutant shows no visible phenotype |
710310 |
