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Literature summary for 3.1.26.11 extracted from

  • Brzezniak, L.; Bijata, M.; Szczesny, R.; Stepien, P.
    Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs (2011), RNA Biol., 8, 616-626.
    View publication on PubMed
Search for more literature for 3.1.26.11

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion isozyme ELAC2 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 gene ELAC2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mt-pre-tRNAArg + H2O
-
 Homo sapiens mt-tRNAArg + 3'-leader of tRNA
-
 ?
mt-pre-tRNAGlu + H2O
-
 Homo sapiens mt-tRNAGlu + 3'-leader of tRNA
-
 ?
mt-pre-tRNAGly + H2O
-
 Homo sapiens mt-tRNAGly + 3'-leader of tRNA
-
 ?
mt-pre-tRNALeu + H2O
-
 Homo sapiens mt-tRNALeu + 3'-leader of tRNA
-
 ?
mt-pre-tRNALys + H2O
-
 Homo sapiens mt-tRNALys + 3'-leader of tRNA
-
 ?
mt-pre-tRNAVal + H2O
-
 Homo sapiens mt-tRNAVal + 3'-leader of tRNA
-
 ?

General Information

General Information Comment Organism
malfunction silencing of the gene MRPP1 encoding a subunit of the enzyme leads to inhibition of both 5' and 3' processing Homo sapiens
physiological function accurate tRNA processing in crucial for mitochondrial genom expression. ELAC2 functions as a mitochondrial tRNase, it cleaves preferentially molecules already processed by mtRNase P Homo sapiens