EC Number   |
General Information |
Reference |
|---|
    2.7.7.9 | evolution |
a feature that discriminates UGPs of different species is the quaternary organization. While UGPs in protists are monomers, di- and tetrameric forms exist in bacteria, and the enzyme from yeast and human are octameric UGPs |
722370 |
| 2.7.7.9 | physiological function |
a knockdown mutant of Ugp1 exhibits an impaired mobilization of glycogen and trehalose as well as a reduction in oxidative stress resistance and long-term cell survival during stationary phase. The modulation of Ugp1 level readjusts glycogen and trehalose accumulation in the protein kinase A-related gene mutants. The protein kinase A-dependent phenotypes of oxidative stress resistance and long-term cell survival are also alleviated via adjustment of Ugp1 level |
737610 |
| 2.7.7.9 | metabolism |
essential enzyme involved in carbohydrate metabolism |
-, 761188 |
| 2.7.7.9 | more |
hUGPs are active in the octameric state and do not dissociate during the enzymatic cycle, structure-function relationships analysis, overview |
722370 |
| 2.7.7.9 | malfunction |
in comparison with wild-type strain V07DF2 and complementation strains, the UGP knocked down mutant 24C9 exhibits sensitivity to sodium dodecyl sulfate (perturbing membrane integrity) and high sodium chloride concentration (high osmotic pressure stress). More than 25% of the conidia of the mutant developed into short and swollen hypha and formed hyperbranching and compact colonies. The mutant exhibits decreased virulence on cotton and tobacco seedlings. The germination of the mutant spores is significantly delayed compared with the wild-type strain on the host roots |
-, 761188 |
| 2.7.7.9 | metabolism |
in sugarcane, UDP-glucose (the product of the reaction) is a branch-point in the carbon channelling into other carbohydrates, such as sucrose and cellulose, which are the major factors for sugarcane productivity |
762236 |
| 2.7.7.9 | metabolism |
involved in cell envelope precursor synthesis |
-, 706591 |
| 2.7.7.9 | metabolism |
involved in sulfolipid synthesis |
706224 |
| 2.7.7.9 | malfunction |
knockdown of rml-1, rml-4 and rml-5 (but not rml-2 and rml-3) causes lethality of the embryo |
747027 |
| 2.7.7.9 | malfunction |
lack of sulfoquinovosyldiacylglycerol in the Arabidopsis ugp3 knockout mutant. The mutant does not show significant differences in glycosides and saccharides between wild type and ugp3 mutants |
723680 |
