EC Number   |
General Information |
Reference  |
|---|
    2.7.7.9 | metabolism |
involved in sulfolipid synthesis |
706224 |
| 2.7.7.9 | metabolism |
involved in cell envelope precursor synthesis |
-, 706591 |
| 2.7.7.9 | more |
structure comparison of human and yeast enzyme, overview |
721537 |
| 2.7.7.9 | more |
structure comparison of human and yeast enzyme, overview. Depolymerization of hUGPase, like in mutant N491P/L492E, results in monomers and higher enzymatic activity |
721537 |
| 2.7.7.9 | physiological function |
the enzyme is essential for survival |
721537 |
| 2.7.7.9 | metabolism |
UDPG-pyrophosphorylase is the key enzyme involved in pullulan biosynthesis and pullulan production by Aureobasidium pullulans |
-, 721973 |
| 2.7.7.9 | metabolism |
the enzyme catalyzes the last and reversible step of the de novo UDP-Glc biosynthetic pathway |
-, 722346 |
| 2.7.7.9 | more |
UDP-Glc is bound in a deep cleft located at the center of the catalytic domain that consists of highly conserved residues |
-, 722346 |
| 2.7.7.9 | physiological function |
UDP-glucose is the onyl precuror for UDP-galactose synthesis, which is one of the sugar nucleotides essentially required for the parasite's survival and infectivity. UDP-glucose is also the glucosyl donor for the unfolded glycoprotein glucosyltransferase involved in glycoprotein quality control in the endoplasmic reticulum and is the presumed donor for the synthesis of base J, i.e. beta-D-glucosyl-hydroxymethyluracil, a rare deoxynucleotide found in telomereproximal DNA in the bloodstream form of the parasite |
-, 722346 |
| 2.7.7.9 | evolution |
a feature that discriminates UGPs of different species is the quaternary organization. While UGPs in protists are monomers, di- and tetrameric forms exist in bacteria, and the enzyme from yeast and human are octameric UGPs |
722370 |
