EC Number   |
General Information |
Reference |
|---|
    2.7.1.147 | evolution |
consensus phylogenetic tree of the ADP-dependent sugar kinases family, evolutionary history of enzyme substrate affinity, reconstruction |
-, 761465 |
| 2.7.1.147 | evolution |
kinetic analyses of the phosphofructokinase annotated enzyme from Methanococcoides burtonii demonstrate that this enzyme is bifunctional. The high conservation of the active site residues of all the enzymes from the order Methanosarcinales suggest that they should be bifunctional, as is reported for the ADP-dependent kinases from Methanococcales, highlighting the redundancy of the glucokinase activity in this archaeal group. In Methanosarcinales two genes have been described. One of them corresponds to a theoretically functional GK enzyme since it presents the GXGD and NXXE catalytic motifs. PFKs from Methanosarcinales should be bifunctional with PFK and GK activities |
-, 760433 |
| 2.7.1.147 | evolution |
kinetic analyses of the phosphofructokinase annotated enzyme from, Methanohalobium evestigatum demonstrate that this enzyme is bifunctional. The high conservation of the active site residues of all the enzymes from the order Methanosarcinales suggest that they should be bifunctional, as is reported for the ADP-dependent kinases from Methanococcales, highlighting the redundancy of the glucokinase activity in this archaeal group. In Methanosarcinales two genes have been described. One of them corresponds to a theoretically functional GK enzyme since it presents the GXGD and NXXE catalytic motifs. PFKs from Methanosarcinales should be bifunctional with PFK and GK activities |
-, 760433 |
| 2.7.1.147 | evolution |
the enzyme belongs to the ADP-dependent phosphofructokinase/glucokinase family. Homology modeling of ADP-dependent sugar kinases from Halobacteria, Methanosarcinales and Eukarya, overview. Models built are divided into four groups based on the taxonomic categorization of the source organism and their ability to grow in high salinity environments as reported in the literature. The groups defined are: Halobacteria, halophilic Methanosarcinales, non-halophilic Methanosarcinales, and Eukarya, the latter used as a control outgroup. Sequences and structures comparisons |
761158 |
| 2.7.1.147 | evolution |
the enzyme belongs to the ADP-dependent phosphofructokinase/glucokinase family. Homology modeling of ADP-dependent sugar kinases from Halobacteria, Methanosarcinales and Eukarya, overview. Models built are divided into four groups based on the taxonomic categorization of the source organism and their ability to grow in high salinity environments as reported in the literature. The groups defined are: Halobacteria, halophilic Methanosarcinales, non-halophilic Methanosarcinales, and Eukarya, the latter used as a control outgroup. Sequences and structures comparisons. Methanohalobium evestigatum posseses a bifunctional MevePFK/GK |
-, 761158 |
| 2.7.1.147 | evolution |
the enzyme belongs to the ADP-dependent phosphofructokinase/glucokinase family. Homology modeling of ADP-dependent sugar kinases from Halobacteria, Methanosarcinales and Eukarya, overview. Models built are divided into four groups based on the taxonomic categorization of the source organism and their ability to grow in high salinity environments as reported in the literature. The groups defined are: Halobacteria, halophilic Methanosarcinales, non-halophilic Methanosarcinales, and Eukarya, the latter used as a control outgroup. Sequences and structures comparisons. Methanosarcina mazei posseses a bifunctional MmazPFK/GK |
-, 761158 |
| 2.7.1.147 | malfunction |
ADPGK knock-out Ramos BL cells display abated in vitro and in vivo tumour aggressiveness, via tumour-macrophage co-culture, migration and Zebrafish xenograft studies. Perturbed glycolysis and visibly reduced markers of Warburg effect in ADPGK knock-out cells, finally leading to apoptosis. Knock-out cells show repression of MYC proto-oncogene, and up to four-fold reduction in accumulated mutations in translocated MYC |
762401 |
| 2.7.1.147 | malfunction |
ADPGK knockdown in zebrafish embryos leads to short, dorsalized body axis induced by elevated apoptosis. ADPGK hypomorphic zebrafish display dysfunctional glucose metabolism |
762457 |
| 2.7.1.147 | malfunction |
down-regulation of ADPGK or GPD2 abundance inhibits oxidative signal generation and induction of NF-kappaB-dependent gene expression, whereas over-expression of ADPGK potentiates them |
721992 |
| 2.7.1.147 | malfunction |
overexpression or suppression of ADPGK does not show any relevant effect |
723169 |
