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Literature summary for 2.7.1.147 extracted from

  • Imle, R.; Wang, B.T.; Stuetzenberger, N.; Birkenhagen, J.; Tandon, A.; Carl, M.; Himmelreich, N.; Thiel, C.; Groene, H.J.; Poschet, G.; Voelkers, M.; Guelow, K.; Schroeder, A.; Carillo, S.; Mittermayr, S.; Bones, J.; Kaminski, M.M.; Koelker, S.; Sauer, S.W.
    ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing (2019), Sci. Rep., 9, 14248 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.1.147

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Danio rerio 5783
-
endoplasmic reticulum
-
 Homo sapiens 5783
-

Organism

Organism UniProt Comment Textmining
Danio rerio
-
-
-
Homo sapiens Q9BRR6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Danio rerio
-
JURKAT cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
ADP-dependent glucokinase
-
 Danio rerio
ADP-dependent glucokinase
-
 Homo sapiens
ADPGK
-
 Danio rerio
ADPGK
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction ADPGK knockdown in zebrafish embryos leads to short, dorsalized body axis induced by elevated apoptosis. ADPGK hypomorphic zebrafish display dysfunctional glucose metabolism Danio rerio
malfunction upon activation, ADPGK knockout Jurkat T cells display increased cell death and ER stress. The increase in cell death results from a metabolic catastrophe and knockout cells displayed severely disturbed energy metabolism hindering induction of Warburg phenotype Homo sapiens
physiological function the enzyme plays a critical role in T cell receptor activation-induced remodeling of energy metabolism. The enzyme is part of a glucose sensing system in the ER modulating metabolism via regulation of N- and O-glycosylation Danio rerio
physiological function the enzyme plays a critical role in T cell receptor activation-induced remodeling of energy metabolism. The enzyme is part of a glucose sensing system in the ER modulating metabolism via regulation of N- and O-glycosylation Homo sapiens