Literature summary for 2.7.1.147 extracted from

Tandon, A.; Birkenhagen, J.; Nagalla, D.; Koelker, S.; Sauer, S.W.
ADP-dependent glucokinase as a novel onco-target for haematological malignancies (2020), Sci. Rep., 10, 13584 .

Search for more literature for 2.7.1.147

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BRR6	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Burkitt lymphoma cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADP + D-glucose	-	Homo sapiens	AMP + D-glucose 6-phosphate	-	?

Synonyms

Synonyms	Comment	Organism
ADP-dependent glucokinase	-	Homo sapiens
ADPGK	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	ADPGK knock-out Ramos BL cells display abated in vitro and in vivo tumour aggressiveness, via tumour-macrophage co-culture, migration and Zebrafish xenograft studies. Perturbed glycolysis and visibly reduced markers of Warburg effect in ADPGK knock-out cells, finally leading to apoptosis. Knock-out cells show repression of MYC proto-oncogene, and up to four-fold reduction in accumulated mutations in translocated MYC	Homo sapiens
physiological function	the enzyme plays a major role in T-cell activation and induction of Warburg effect	Homo sapiens

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Release 2023.1 (January 2023)