EC Number   |
General Information |
Reference |
|---|
    2.6.1.7 | evolution |
kynurenine aminotransferase 3 (KAT3, EC 2.6.1.7) catalyzes the transamination of kynurenine to kynurenic acid, and is identical to cysteine conjugate beta-lyase 2 (CCBL2, EC 4.4.1.13) and glutamine transaminase L (GTL, EC 2.6.1.64) |
746952 |
| 2.6.1.7 | more |
the enzyme is a key enzyme for studying the nephrotoxic mechanism of some xenobiotics and the formation of chemopreventive compounds in the mouse kidney |
746952 |
| 2.6.1.7 | physiological function |
acute administration of the KAT II inhibitor (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one is associated with a short-onset, time-dependent decrease in firing rate and burst activity of dopamine neurons, both parameters reaching a 50% reduction within 45 min. (3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one reduces the number of spontaneously active dopamine cells. Pretreatment with D-cycloserine or [3-[[(3,4-dichlorophenyl)methyl]amino]propyl](diethoxy-methyl) phosphinic acid (CGP-52432) prevents the inhibitory action of (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one. Pretreatment with methyllycaconitine does not change the response, whereas picrotoxin partially prevents the inhibitory effects of (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one |
739176 |
| 2.6.1.7 | physiological function |
KAT-II is the enzymatic isoform that mainly accounts for the synthesis of cerebral kynurenic acid |
702455 |
| 2.6.1.7 | physiological function |
kynurenine aminotransferase 3 (KAT3) catalyzes the transamination of kynurenine to kynurenic acid |
746952 |
