EC Number   |
General Information |
Reference  |
|---|
   3.4.21.92 | malfunction |
a point mutation from G to A at nucleotide 2317 of ClpC1 on chromosome V of Arabidopsis is responsible for the irm1 phenotype (typical Fe-deficiency chlorosis) |
717092 |
| 3.4.21.92 | physiological function |
ClpC1 is involved in Fe homeostasis in leaves |
717092 |
| 3.4.21.92 | physiological function |
ClpP enhances the unfolding activity of ClpX |
717472 |
| 3.4.21.92 | malfunction |
deletion of clpX and clpP suppresses temperature-sensitive filamentation of cells carrying the ftsZ84 allele and reduces FtsZ84 degradation, consistent with ClpXP (two-component protease composed of ClpX and ClpP) playing a role in modulating the level of FtsZ (a tubulin-like protein) |
717731 |
| 3.4.21.92 | malfunction |
in a division-defective strain, DELTAminC, the additional deletion of clpX or clpP delays cell division and exacerbates filamentation |
717731 |
| 3.4.21.92 | malfunction |
ClpP1 is essential for viability. The gene can only be deleted from the chromosome when a second functional copy is provided. Over-expression of clpP1 has no effect on growth in aerobic culture or viability under anaerobic conditions or during nutrient starvation |
717738 |
| 3.4.21.92 | malfunction |
clpP2 over-expression is toxic |
717738 |
| 3.4.21.92 | physiological function |
ClpXP protease of Escherichia coli consists of the AAA+ ClpX unfoldase and the associated ClpP compartmental peptidase. Once the substrate is unfolded, ClpX translocates the unfolded polypeptide into the degradation chamber of ClpP in steps of five to eight amino acids per power stroke |
717999 |
| 3.4.21.92 | malfunction |
in a DELTAclpP strain, 288 genes show significant changes in relative transcript amounts as compared with the parent. Similarly, 242 genes are differentially expressed by a DELTAclpX strain. Several genes associated with cell growth are down-regulated in both mutants, consistent with the slow-growth phenotype of the DELTAclp strains. Among the up-regulated genes are those encoding enzymes required for the biosynthesis of intracellular polysaccharides and malolactic fermentation. Expression of several genes known or predicted to be involved in competence and mutacin production are down-regulated in the DELTAclp strains |
718088 |
| 3.4.21.92 | malfunction |
both FlhD and FlhC regulator proteins accumulate markedly following ClpXP depletion, and their half-lives are significantly longer in the mutant cells |
718089 |
