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Literature summary for 3.4.21.92 extracted from
- Dual regulatory pathways of flagellar gene expression by ClpXP protease in enterohaemorrhagic Escherichia coli (2011), Microbiology, 157, 3094-3103.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
enterohaemorrhagic Escherichia coli, EHEC | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ClpXP protease | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | both FlhD and FlhC regulator proteins accumulate markedly following ClpXP depletion, and their half-lives are significantly longer in the mutant cells | Escherichia coli |
| physiological function | ClpXP protease tightly regulates the flagellar expression by degrading the FlhD/FlhC master regulator in EHEC. The flagellar regulon in EHEC might be controlled by ClpXP protease through two pathways, namely post-translational control of the FlhD/FlhC master regulator by degrading them and transcriptional control of the flhDC operon through the locus of enterocyte effacement (LEE)-encoded GrlR-GrlA regulatory system | Escherichia coli |
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