EC Number |
General Information |
Reference |
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3.4.21.92 | malfunction |
a point mutation from G to A at nucleotide 2317 of ClpC1 on chromosome V of Arabidopsis is responsible for the irm1 phenotype (typical Fe-deficiency chlorosis) |
717092 |
3.4.21.92 | malfunction |
both FlhD and FlhC regulator proteins accumulate markedly following ClpXP depletion, and their half-lives are significantly longer in the mutant cells |
718089 |
3.4.21.92 | malfunction |
ClpP1 is essential for viability. The gene can only be deleted from the chromosome when a second functional copy is provided. Over-expression of clpP1 has no effect on growth in aerobic culture or viability under anaerobic conditions or during nutrient starvation |
717738 |
3.4.21.92 | malfunction |
clpP2 over-expression is toxic |
717738 |
3.4.21.92 | malfunction |
deletion of clpX and clpP suppresses temperature-sensitive filamentation of cells carrying the ftsZ84 allele and reduces FtsZ84 degradation, consistent with ClpXP (two-component protease composed of ClpX and ClpP) playing a role in modulating the level of FtsZ (a tubulin-like protein) |
717731 |
3.4.21.92 | malfunction |
in a DELTAclpP strain, 288 genes show significant changes in relative transcript amounts as compared with the parent. Similarly, 242 genes are differentially expressed by a DELTAclpX strain. Several genes associated with cell growth are down-regulated in both mutants, consistent with the slow-growth phenotype of the DELTAclp strains. Among the up-regulated genes are those encoding enzymes required for the biosynthesis of intracellular polysaccharides and malolactic fermentation. Expression of several genes known or predicted to be involved in competence and mutacin production are down-regulated in the DELTAclp strains |
718088 |
3.4.21.92 | malfunction |
in a division-defective strain, DELTAminC, the additional deletion of clpX or clpP delays cell division and exacerbates filamentation |
717731 |
3.4.21.92 | metabolism |
presence of ATP favours assembly and ADP dissociation of the hexameric assembly. Subunit exchange kinetics is at least one order of magnitude slower than the ATP hydrolysis rate, and ClpB dynamics and activity are related processe. DnaK and substrate proteins regulate the ATPase activity and dynamics of ClpB |
-, 752706 |
3.4.21.92 | physiological function |
a mutant strain lacking the N-terminal domain of ClpX is not viable |
732530 |
3.4.21.92 | physiological function |
accessory proteins ClpT1 and ClpT2 regulate the assembly of the Clp proteolytic core in vascular plants |
718212 |