EC Number   |
General Information |
Reference |
|---|
   3.4.21.117 | physiological function |
the enzyme is involved in skin homeostasis and inflammation. Excess of enzyme activity is also associated with tumor metastasis processes, especially in ovarian carcinomas, prostatic and pancreatic cancers |
731754 |
| 3.4.21.117 | physiological function |
the enzyme plays roles in physiological and pathological skin desquamation processes that requires the presence of water in the stratum corneum, which is maintained by hygroscopic compounds collectively named as skin moisturizing factor |
731367 |
| 3.4.21.117 | physiological function |
the serine proteases kallikrein 5 and kallikrein 7 control enzymatic processing of cathelicidin precursor in the skin and regulate the eventual function of the final forms of these peptides |
709408 |
| 3.4.21.117 | physiological function |
the treatment of beta-amyloid oligomer preparations with the enzyme, but not the inactive proform, significantly reduces Abeta42-mediated toxicity to rat hippocampal neurons to the same extent as the known Abeta-degrading protease insulin-degrading enzyme |
731403 |
