3.4.21.117	evolution	human kallikrein-related peptidase 7 is one member from a cluster of 15 serine peptidases of the chymotrypsin-like S1A family clan PA(S) sharing a high degree of identity and localized at human chromosome locus 19q13.4	731367	
3.4.21.117	evolution	human tissue kallikrein-7 is a chymotryptic serine protease member of tissue kallikrein family.	731754	
3.4.21.117	malfunction	kallikrein 7 may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion	708770	
3.4.21.117	malfunction	KLK7 is upregulated in epithelial ovarian carcinoma with high levels correlated with poor prognosis. Mechanism for association of high KLK7 levels with chemoresistance and poor prognosis for serous EOC patients by promotion of peritoneal dissemination and reinvasion via increased MCA and alpha5beta1 integrin-dependent cell adhesion	707990	
3.4.21.117	physiological function	inhibition of KLK7 alone is sufficient to block shedding, whereas KLK5 is also a major contributor	754355	
3.4.21.117	physiological function	kallikrein 7 is a proteolytic enzyme important for epithelial cell shedding	708770	
3.4.21.117	physiological function	kallikrein 7 is a proteolytic enzyme important for epithelial cell shedding, the enzyme is involved in the degradation of several components of the extracellular matrix	732451	
3.4.21.117	physiological function	KLK7 overexpression in melanoma cells mediates decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of alpha5/beta1/alphav/beta3 integrin expression. Upregulation of MCAM/CD146 and increased spheroid formation is also detected	752892	
3.4.21.117	physiological function	KLK7-mediated cleavage of midkine results in an overall reduction in the pro-proliferative and pro-migratory effect of midkine. An inverse relation between KLK7 and midkine is also observed in human melanoma tissues	754113	
3.4.21.117	physiological function	serine proteases of the tissue kallikrein-related peptidases family are implicated in tumorigenesis, kallikrein-related peptidase 7 is a proliferative factor that is aberrantly expressed in human colon cancer and involved in cell proliferation in vitro and in vivo	731402	
3.4.21.117	physiological function	the enzyme is involved in skin homeostasis and inflammation. Excess of enzyme activity is also associated with tumor metastasis processes, especially in ovarian carcinomas, prostatic and pancreatic cancers	731754	
3.4.21.117	physiological function	the enzyme plays roles in physiological and pathological skin desquamation processes that requires the presence of water in the stratum corneum, which is maintained by hygroscopic compounds collectively named as skin moisturizing factor	731367	
3.4.21.117	physiological function	the serine proteases kallikrein 5 and kallikrein 7 control enzymatic processing of cathelicidin precursor in the skin and regulate the eventual function of the final forms of these peptides	709408	
3.4.21.117	physiological function	the treatment of beta-amyloid oligomer preparations with the enzyme, but not the inactive proform, significantly reduces Abeta42-mediated toxicity to rat hippocampal neurons to the same extent as the known Abeta-degrading protease insulin-degrading enzyme	731403