Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid peptide + H2O | Rattus norvegicus | degradation, the enzyme cleaves after both Phe residues within the core of Abeta42 in vitro, thereby inhibiting A? fibril formation and promoting the degradation of preformed fibrils | ? | - |
? | |
additional information | Rattus norvegicus | the enzyme shows a unique extended chymotrypsin-like specificity and beta-amyloid peptide-degrading capacity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-amyloid peptide + H2O | degradation | Rattus norvegicus | ? | - |
? | |
beta-amyloid peptide + H2O | degradation, the enzyme cleaves after both Phe residues within the core of Abeta42 in vitro, thereby inhibiting A? fibril formation and promoting the degradation of preformed fibrils | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme shows a unique extended chymotrypsin-like specificity and beta-amyloid peptide-degrading capacity | Rattus norvegicus | ? | - |
? | |
additional information | the enzyme's consensus motif is RX0(Y/F)-/-(Y/F)-/-(S/A/G/T) or RX0(Y/F)-/-(S/T/A) (0 = hydrophobic) | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
kallikrein 7 | - |
Rattus norvegicus |
KLK7 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | the treatment of beta-amyloid oligomer preparations with the enzyme, but not the inactive proform, significantly reduces Abeta42-mediated toxicity to rat hippocampal neurons to the same extent as the known Abeta-degrading protease insulin-degrading enzyme | Rattus norvegicus |