EC Number   |
General Information |
Reference |
|---|
    2.7.1.35 | physiological function |
biotransformation of pyridoxal to pyridoxal 5'-phosphate (PLP) by pyridoxal kinase (pdxY) supports cadaverine production in Escherichia coli. PLP is an essential cofactor of lysine decarboxylase and the major bottleneck in the cadaverine biosynthesis pathway |
759126 |
| 2.7.1.35 | physiological function |
in eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5'-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. PDXK converts PLP precursors such as pyridoxal (PL), pyridoxamine (PM) and pyridoxine (PN) taken from food into PLP, PMP and PNP, respectively. PNPO catalyzes the oxidation of PMP and PNP into PLP. PLP performs many functions by working as coenzyme for a wide number of enzymes which control amino acid, lipid and carbohydrate metabolism |
760178 |
| 2.7.1.35 | physiological function |
pyridoxal kinase (PdxK) is an important enzyme of the vitamin B6 salvage pathway which is required for phosphorylation of B6 vitamers |
-, 759342 |
| 2.7.1.35 | physiological function |
pyridoxal kinase is a key enzyme in the metabolism of vitamin B6 |
722183 |
| 2.7.1.35 | physiological function |
pyridoxine/pyridoxal kinase (PdxK) belongs to the ribokinase family and is involved in the vitamin B6 salvage pathway by phosphorylating pyridoxal (PL) into an active form. In the human malaria parasite, Plasmodium falciparum, PfPdxK functions to salvage vitamin B6 from both itself and its host |
759093 |
| 2.7.1.35 | physiological function |
the enzyme is essential for growth of Trypanosoma brucei in vitro and for infectivity in mice |
723219 |
| 2.7.1.35 | physiological function |
the enzyme pyridoxal kinase (PdxK) catalyzes the conversion of pyridoxal to pyridoxal 5'-phosphate (PLP) using ATP as the cosubstrate. The product PLP plays a key role in several biological processes such as transamination, decarboxylation and deamination |
-, 759346 |
| 2.7.1.35 | physiological function |
the SOS4 pyridoxal kinase is required for maintenance of vitamin B6-mediated processes in chloroplasts. SOS4 is required for maintenance of phosphorylated B6 vitamer concentrations in chloroplasts |
723449 |
| 2.7.1.35 | physiological function |
vitamin B6 enters the cells after hydrolysis of the phosphorylated forms by the membrane-bound tissue non-specific alkaline phosphatase (TNSALP, EC 3.1.3.1). Once inside the cells, pyridoxal kinase (PL kinase, PDXK, EC 2.7.1.35) phosphorylates the hydroxymethyl group of PL, PN and PM to their respective 5'-phosphate forms |
758844 |
