   1.2.1.36 | physiological function |
the cytosolic isozymes ALDH1A1, ALDH1A2, and ALDH1A3 play important roles in cell signaling via oxidation of retinaldehyde to retinoic acid. In the cell, retinoic acid produced in the cytoplasm binds to cellular retinoic acid binding protein type II, and is transferred to the nucleus where it binds to heterodimers of retinoic acid receptor (RAR) and retinoid X receptor (RXR). Once activated, these receptor complexes bind to retinoic acid response elements (RAREs), which are regulatory sequences that induce gene transcription and modulate a wide range of biological processes, including cell proliferation, differentiation, cell cycle arrest and apoptosis |
762901 |
