EC Number   |
General Information |
Reference |
|---|
   1.2.1.36 | more |
high-fat diet significantly decreases basal retinal levels in liver to 44% of control rats. Enhanced activity and expression of RALDHs in liver of high-fat diet rats |
-, 743142 |
| 1.2.1.36 | more |
MAPK activation is required for GM-CSF-induced Aldh1a2 expression and Sp1 nuclear translocation. Sp1 participates in the Aldh1a2 expression. CpG methylation in the Aldh1a2 promoter region inhibits Sp1-dependent Aldh1a2 promoter activation. Aldh1a2 transcription silencing by CpG methylation of the promoter region is not due to direct interference with Sp1 binding to the promoter region |
-, 743660 |
| 1.2.1.36 | physiological function |
aldehyde dehydrogenase 1A1 increases NADH levels and promotes tumor growth via glutathione/dihydrolipoic acid-dependent NAD+ reduction. ALDH1A1 can also use glutathione (GSH) and dihydrolipoic acid (DHLA) as electron donors to reduce NAD+ to NADH. The GSH/DHLA-dependent NAD+-reduction activity of ALDH1A1 is not affected by the aldehyde dehydrogenase inhibitor or by mutation of the residues in its aldehyde-binding pocket. It is thus a distinct biochemical reaction from the classic aldehyde-dehydrogenase activity catalyzed by ALDH1A1. The GSH/DHLA-dependent NAD+-reduction activity of ALDH1A1 can decrease cellular NAD(P)+/NAD(P)H ratio and promote tumor growth. The tumor-promoting effect of ALDH1A1 is achieved, at least partially, through decreasing the cellular NAD+/ NADH ratio |
763529 |
| 1.2.1.36 | physiological function |
ALDH1A1 contributes to protection of A-549 cells against retinaldehyde toxicity. ALDH1 confers protection against retinaldehyde toxicity in cancer cells |
763530 |
| 1.2.1.36 | physiological function |
ALDH1A1 is a NAD+-dependent aldehyde dehydrogenase that participates in multiple metabolic pathways and has been indicated to play an important role in obesity and diabetes |
762790 |
| 1.2.1.36 | physiological function |
changes in ALDH1A1 expression appear to be part of the early acute-phase inflammatory response, which alters the expression of other retinoid homeostatic genes |
743375 |
| 1.2.1.36 | physiological function |
enzyme BcALDH is an atypical aldehyde dehydrogenase having bidirectional oxidizing and reducing activities |
763136 |
| 1.2.1.36 | physiological function |
isoform RALDH2 expression in dendritic cells is critical to control acute graft-versus-host disease lethality |
763337 |
| 1.2.1.36 | physiological function |
retinal dehydrogenase 5 is an important enzyme in the visual cycle and plays a crucial role in suppressing proliferation and metastasis in hepatocellular carcinoma |
763150 |
| 1.2.1.36 | physiological function |
retinaldehyde dehydrogenase 2 is required to activate retinoic acid signaling at the onset of gastrulation |
711830 |
