EC Number |
Expression |
Reference |
---|
1.14.99.38 | up |
induction of Ch25h is JAK- and STAT1-dependent, overview |
-, 715833 |
1.14.99.38 | up |
activation of the innate immune system by TLR ligands induces 25-hydroxycholesterol production which results in suppression of IgA class switching in B cells |
727109 |
1.14.99.38 | up |
both IFN-alpha- and IFN-gamma induce the enzyme in bone marrow-derived macrophages |
727611 |
1.14.99.38 | up |
induction of CYP3A by pregnenolone-16 alpha-carbonitrile causes accumulation of 25-hydroxycholesterol in cell line AML12 derived from mouse liver, the induction is not suppressed by the addition of desmosterol. Although the transcription of Ch25h is also upregulated by addition of pregnenolone-16 alpha-carbonitrile, the protein level of CH25H is not elevated. Desmosterol does not affect the expression of cellular CYP3A protein, but CH25H protein level is obviously decreased by desmosterol treatment |
728088 |
1.14.99.38 | up |
vasoprotective stimuli such as pulsatile shear stress and statins increase the expression of the enzyme via Krueppel-like factor 4 |
744738 |
1.14.99.38 | up |
the enzyme expression in primary human hepatocytes is primarily and transiently induced by type I interferon. Infection with hepatitis C virus causes up-regulation of the enzyme in vivo |
745051 |
1.14.99.38 | up |
pseudorabies virus infection of porcine alveolar macrophages is attenuated by enzyme overexpression (24 h post infection) |
745479 |
1.14.99.38 | up |
the enzyme expression is induced by feeding a Western diet |
745518 |
1.14.99.38 | more |
enzyme expression is not induced by interferons in human cells and knockdown of STAT-1 has no effect on the induction of the enzyme |
745657 |
1.14.99.38 | up |
the enzyme is upregulated upon poly(I:C) treatment or hepatitis C virus infection in hepatocytes |
745657 |