BRENDA - Enzyme Database show
show all sequences of 1.14.99.38

On the formation and possible biological role of 25-hydroxycholesterol

Diczfalusy, U.; Biochimie 95, 455-460 (2013)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
the gene encoding the enzyme is located on chromosome 10
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Homo sapiens
16020
-
membrane
-
Mus musculus
16020
-
membrane
-
Rattus norvegicus
16020
-
membrane
-
Sus scrofa
16020
-
microsome
-
Homo sapiens
-
-
microsome
-
Mus musculus
-
-
mitochondrion
-
Mus musculus
5739
-
mitochondrion
-
Rattus norvegicus
5739
-
mitochondrion
-
Sus scrofa
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cholesterol + AH2 + O2
Rattus norvegicus
-
25-hydroxycholesterol + A + H2O
-
-
?
cholesterol + AH2 + O2
Sus scrofa
-
25-hydroxycholesterol + A + H2O
-
-
?
cholesterol + AH2 + O2
Homo sapiens
the reaction might be catalyzed by CYP3A4
25-hydroxycholesterol + A + H2O
-
-
?
cholesterol + AH2 + O2
Mus musculus
the reaction might be catalyzed by CYP3A4
25-hydroxycholesterol + A + H2O
-
-
?
additional information
Rattus norvegicus
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
additional information
Sus scrofa
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
additional information
Homo sapiens
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
additional information
Mus musculus
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q02318
activity of EC 1.14.99.15 and 1.14.99.38
-
Mus musculus
Q64459
-
-
Rattus norvegicus
-
-
-
Sus scrofa
-
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
alveolar macrophage
-
Homo sapiens
-
brain
-
Homo sapiens
-
heart
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
hepatocyte
-
Rattus norvegicus
-
hepatocyte
-
Homo sapiens
-
kidney
-
Homo sapiens
-
liver
low expression of cholesterol 25-hydroxylase
Homo sapiens
-
liver
low expression of cholesterol 25-hydroxylase
Mus musculus
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
lung
patients with chronic obstructive pulmonary disease have increased expression of cholesterol 25-hydroxylase in the lung
Homo sapiens
-
pneumocyte
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cholesterol + AH2 + O2
-
727109
Rattus norvegicus
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
-
727109
Sus scrofa
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
-
727109
Homo sapiens
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
-
727109
Mus musculus
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
the reaction might be catalyzed by CYP3A4
727109
Homo sapiens
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
the reaction might be catalyzed by CYP3A4
727109
Mus musculus
25-hydroxycholesterol + A + H2O
-
-
-
?
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Rattus norvegicus
?
-
-
-
-
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Sus scrofa
?
-
-
-
-
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Homo sapiens
?
-
-
-
-
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Mus musculus
?
-
-
-
-
Cloned(Commentary) (protein specific)
Commentary
Organism
the gene encoding the enzyme is located on chromosome 10
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Homo sapiens
16020
-
membrane
-
Mus musculus
16020
-
membrane
-
Rattus norvegicus
16020
-
membrane
-
Sus scrofa
16020
-
microsome
-
Homo sapiens
-
-
microsome
-
Mus musculus
-
-
mitochondrion
-
Mus musculus
5739
-
mitochondrion
-
Rattus norvegicus
5739
-
mitochondrion
-
Sus scrofa
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
cholesterol + AH2 + O2
Rattus norvegicus
-
25-hydroxycholesterol + A + H2O
-
-
?
cholesterol + AH2 + O2
Sus scrofa
-
25-hydroxycholesterol + A + H2O
-
-
?
cholesterol + AH2 + O2
Homo sapiens
the reaction might be catalyzed by CYP3A4
25-hydroxycholesterol + A + H2O
-
-
?
cholesterol + AH2 + O2
Mus musculus
the reaction might be catalyzed by CYP3A4
25-hydroxycholesterol + A + H2O
-
-
?
additional information
Rattus norvegicus
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
additional information
Sus scrofa
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
additional information
Homo sapiens
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
additional information
Mus musculus
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
alveolar macrophage
-
Homo sapiens
-
brain
-
Homo sapiens
-
heart
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-
hepatocyte
-
Homo sapiens
-
hepatocyte
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
liver
low expression of cholesterol 25-hydroxylase
Homo sapiens
-
liver
low expression of cholesterol 25-hydroxylase
Mus musculus
-
liver
-
Rattus norvegicus
-
liver
-
Sus scrofa
-
lung
patients with chronic obstructive pulmonary disease have increased expression of cholesterol 25-hydroxylase in the lung
Homo sapiens
-
pneumocyte
-
Homo sapiens
-
THP-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
cholesterol + AH2 + O2
-
727109
Rattus norvegicus
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
-
727109
Sus scrofa
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
-
727109
Homo sapiens
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
-
727109
Mus musculus
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
the reaction might be catalyzed by CYP3A4
727109
Homo sapiens
25-hydroxycholesterol + A + H2O
-
-
-
?
cholesterol + AH2 + O2
the reaction might be catalyzed by CYP3A4
727109
Mus musculus
25-hydroxycholesterol + A + H2O
-
-
-
?
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Rattus norvegicus
?
-
-
-
-
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Sus scrofa
?
-
-
-
-
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Homo sapiens
?
-
-
-
-
additional information
25-hydroxycholesterol is a secondary autoxidation product derived from 3beta-hydroxy-cholest-5-ene-25-hydroperoxide, a hydroperoxide identified in air-aged cholesterol. Thermal decomposition of 3beta-hydroxy-cholest-5-ene-25-hydroperoxide gives rise to 25-hydroxycholesterol
727109
Mus musculus
?
-
-
-
-
Expression
Organism
Commentary
Expression
Mus musculus
activation of the innate immune system by TLR ligands induces 25-hydroxycholesterol production which results in suppression of IgA class switching in B cells
up
General Information
General Information
Commentary
Organism
malfunction
patients with hereditary spastic paresis, a rare inherited disease with mutations in the CYP7B1 gene, have highly elevated levels of 25- and 27-hydroxycholesterol but normal levels of cholesterol and bile acids
Homo sapiens
malfunction
mice with a disruption in the cholesterol 25-hydroxylase gene regulate cholesterol metabolism normally. Ch25h-/- mice have higher levels of mRNAs coding for immunoglobulin A and immunoglobulin J. Disruption in the Cyp7b1 gene leads to significantly increased levels of 25-hydroxycholesterol in the circulation, and to significantly lower levels of IgA compared to wild-type mice
Mus musculus
additional information
the high concentrations of vitamin D3 metabolites required for upregulation of the cholesterol 25-hydroxylase gene makes it unlikely that these metabolites are important regulators of cholesterol 25-hydroxylase in vivo
Homo sapiens
additional information
25-hydroxycholesterol does not stimulate the sPLA2-IIA promoter in the mouse Schwann cell line MSC80
Mus musculus
physiological function
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol is, however, a weak activator of the liver X receptors. 25-Hydroxycholesterol is of great importance for maintaining cholesterol homeostasis. 25-Hydroxycholesterol induces the secretion of the proinflammatory cytokine IL-8
Homo sapiens
physiological function
important role for 25-hydroxycholesterol in the immune system. High concentrations of 25-hydroxycholesterol induce apoptosis in a mouse oligodendrocyte cell line 158N in an liver X receptor-independent manner. Treatment of these cells with 25-hydroxycholesterol results in enhanced secreted phospholipase A2 activity
Mus musculus
physiological function
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol decreases the level of cytoplasmic IkBa and increases the nuclear NFkB level, its sulfated form has the opposite effects
Rattus norvegicus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
patients with hereditary spastic paresis, a rare inherited disease with mutations in the CYP7B1 gene, have highly elevated levels of 25- and 27-hydroxycholesterol but normal levels of cholesterol and bile acids
Homo sapiens
malfunction
mice with a disruption in the cholesterol 25-hydroxylase gene regulate cholesterol metabolism normally. Ch25h-/- mice have higher levels of mRNAs coding for immunoglobulin A and immunoglobulin J. Disruption in the Cyp7b1 gene leads to significantly increased levels of 25-hydroxycholesterol in the circulation, and to significantly lower levels of IgA compared to wild-type mice
Mus musculus
additional information
the high concentrations of vitamin D3 metabolites required for upregulation of the cholesterol 25-hydroxylase gene makes it unlikely that these metabolites are important regulators of cholesterol 25-hydroxylase in vivo
Homo sapiens
additional information
25-hydroxycholesterol does not stimulate the sPLA2-IIA promoter in the mouse Schwann cell line MSC80
Mus musculus
physiological function
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol is, however, a weak activator of the liver X receptors. 25-Hydroxycholesterol is of great importance for maintaining cholesterol homeostasis. 25-Hydroxycholesterol induces the secretion of the proinflammatory cytokine IL-8
Homo sapiens
physiological function
important role for 25-hydroxycholesterol in the immune system. High concentrations of 25-hydroxycholesterol induce apoptosis in a mouse oligodendrocyte cell line 158N in an liver X receptor-independent manner. Treatment of these cells with 25-hydroxycholesterol results in enhanced secreted phospholipase A2 activity
Mus musculus
physiological function
formation of 25-hydroxycholesterol in liver mitochondria is dependent on CYP27A1, and the 25-hydroxycholesterol formed is subsequently sulfated by the insulin-regulated cytosolic sulfotransferase 2B1b. 25-Hydroxycholesterol decreases the level of cytoplasmic IkBa and increases the nuclear NFkB level, its sulfated form has the opposite effects
Rattus norvegicus
Expression (protein specific)
Organism
Commentary
Expression
Mus musculus
activation of the innate immune system by TLR ligands induces 25-hydroxycholesterol production which results in suppression of IgA class switching in B cells
up
Other publictions for EC 1.14.99.38
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744738
Li
Krueppel-like factor 4 regula ...
Mus musculus
Circulation
136
1315-1330
2017
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1
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2
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1
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1
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1
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745450
Noebauer
Hepatic cholesterol-25-hydrox ...
Mus musculus
J. Diabetes Res.
2017
4108768
2017
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-
-
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1
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3
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1
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2
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1
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1
1
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745479
Wang
Cholesterol 25-hydroxylase ac ...
Sus scrofa
J. Gen. Virol.
98
1467-1476
2017
-
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1
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1
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3
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1
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1
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2
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1
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1
1
1
1
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745518
Mukherjee
Transgenic tomatoes expressin ...
Mus musculus
J. Lipid Res.
58
1636-1647
2017
-
-
-
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1
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3
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4
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1
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1
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4
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1
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1
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1
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-
745658
Ke
Cholesterol 25-hydroxylase in ...
Sus scrofa
J. Virol.
91
e00827-17
2017
-
-
1
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1
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1
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6
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2
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1
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1
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1
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1
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2
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1
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-
-
1
1
1
1
-
-
745051
Anggakusuma
Interferon-inducible choleste ...
Homo sapiens
Hepatology
62
702-714
2015
-
-
-
-
-
-
-
-
1
-
-
1
-
5
-
-
-
-
-
3
-
-
1
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1
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1
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3
-
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1
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-
-
-
-
-
-
-
-
1
1
1
1
-
-
745657
Xiang
Identification of cholesterol ...
Homo sapiens
J. Virol.
89
6805-6816
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
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-
2
-
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1
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1
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2
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1
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2
1
1
2
-
-
746440
Tsujioka
Five-aza-2-deoxycytidine-indu ...
Homo sapiens
Sci. Rep.
5
16709
2015
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
-
1
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1
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4
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1
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-
-
-
-
-
-
2
1
1
2
-
-
746435
Chen
Interferon-inducible choleste ...
Homo sapiens
Sci. Rep.
4
7242
2014
-
-
1
-
1
-
-
-
-
-
-
1
-
4
-
-
-
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