EC Number   |
Expression |
Reference |
|---|
   2.3.1.B41 | down |
minute cholesterol crystals significantly suppress SIRT6 expression in endothelial cells |
756672 |
| 2.3.1.B41 | up |
several factors regulate the expression of the SIRT6 gene. Notably, in a tumor-suppressing pathway, c-FOS binds to an AP-1 binding site (TAAGTCA) at the SIRT6 promoter, activating SIRT6 gene expression. In addition to the positive regulators of SIRT6, various chromatin factors negatively control the gene expression of SIRT6. presence of PJ-34, a PARP1 inhibitor, results in enhanced mRNA level of nuclear SIRT6 |
757931 |
| 2.3.1.B41 | down |
several factors regulate the expression of the SIRT6 gene. PARP1 may inhibit the expression of SIRT6, and the presence of PJ-34, a PARP1 inhibitor, results in enhanced mRNA level of nuclear SIRT6. A role for the transcription factor E2F1 as an enhancer of glycolysis and inhibitor of the expression of SIRT6. E2F1 directly binds the SIRT6 promoter and suppresses SIRT6 promoter activity under both normoxic and hypoxic culture conditions. In embryos and neural stem cells, SIRT6 expression becomes suppressed by maternal diabetes in vivo or high glucose in vitro through oxidative stress |
757931 |
| 2.3.1.B41 | down |
several factors regulate the expression of the SIRT6 gene. PARP1 may inhibit the expression of SIRT6, and the presence of PJ-34, a PARP1 inhibitor, results in enhanced mRNA level of nuclear SIRT6. A role for the transcription factor E2F1 as an enhancer of glycolysis and inhibitor of the expression of SIRT6. E2F1 directly binds the SIRT6 promoter and suppresses SIRT6 promoter activity under both normoxic and hypoxic culture conditions. In neural stem cells, SIRT6 expression becomes suppressed by maternal diabetes in vivo or high glucose in vitro through oxidative stress |
757931 |
| 2.3.1.B41 | up |
SIRT6 expression is upregulated under pathologic conditions in angiotensin II-stimulated cardiac fibroblasts and in myocardium of rat subjected to abdominal aortic constriction surgery |
739733 |
| 2.3.1.B41 | down |
SIRT6 is down-regulated in human glioma tissues |
729145 |
| 2.3.1.B41 | up |
SIRT6 is upregulated in squamous cell carcinoma |
729520 |
