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Literature summary for 2.3.1.B41 extracted from

  • Ming, M.; Han, W.; Zhao, B.; Sundaresan, N.R.; Deng, C.X.; Gupta, M.P.; He, Y.Y.
    SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer (2014), Cancer Res., 74, 5925-5933.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B41

Application

Application Comment Organism
medicine the oncogenic role of SIRT6 in skin cancer suggest SIRT6 as a potential target for developing chemopreventive strategies to reduce the skin cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-
Mus musculus P59941
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte epidermal Homo sapiens
-
skin
-
 Mus musculus
-
skin sun-protected normal skin Homo sapiens
-
squamous cell carcinoma cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
SIRT6
-
 Homo sapiens
SIRT6
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens SIRT6 is upregulated in squamous cell carcinoma up

General Information

General Information Comment Organism
malfunction SIRT6 loss suppresses proliferation and epidermal hyperplasia in mouse skin. Skin-specific deletion of SIRT6 in the mouse inhibits skin tumorigenesis Mus musculus
metabolism SIRT6 upregulates COX-2 levels and acts as an oncogene in skin carcinogenesis Homo sapiens
metabolism SIRT6 upregulates COX-2 levels and acts as an oncogene in skin carcinogenesis Mus musculus