Cloned (Comment) | Organism |
---|---|
gene SIRT6, real-time PCR enzyme expression analysis | Homo sapiens |
gene SIRT6, real-time PCR enzyme expression analysis | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of endothelium-specific SIRT6 knockout mice (Tie2-Cre/SIRT6flox/flox, defined as ecSIRT6-/-). Analysis of the effect of endothelium-specific SIRT6 depletion on hyperlipidemic mice | Mus musculus |
additional information | generation of SIRT6-overexpressing human umbilical vein endothelial cells (HUVECS), significantly fewer THP-1 cells adher to SIRT6-overexpressing HUVECs exposed to minute CCs compared to control HUVECs | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8N6T7 | - |
- |
Mus musculus | P59941 | Apoe-/- mice, Tie2-Cre mice, and SIRT6-floxed (SIRT6flox/flox) mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | - |
Mus musculus | - |
endothelial cell | - |
Homo sapiens | - |
endothelial cell | - |
Mus musculus | - |
endothelium | - |
Homo sapiens | - |
endothelium | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
HUVEC cell | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
lung | - |
Mus musculus | - |
spleen | - |
Mus musculus | - |
umbilical vein endothelial cell | - |
Homo sapiens | - |
vascular endothelial cell | - |
Homo sapiens | - |
vascular endothelial cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
nicotinamide adenine dinucleotide-dependent deacetylase | - |
Homo sapiens |
nicotinamide adenine dinucleotide-dependent deacetylase | - |
Mus musculus |
SIRT6 | - |
Homo sapiens |
SIRT6 | - |
Mus musculus |
sirtuin 6 | - |
Homo sapiens |
sirtuin 6 | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens | |
NAD+ | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | minute cholesterol crystals significantly suppress SIRT6 expression in endothelial cells | down |
Mus musculus | minute cholesterol crystals significantly suppress SIRT6 expression in endothelial cells | down |
General Information | Comment | Organism |
---|---|---|
malfunction | minute cholesterol crystals (CCs) significantly suppress SIRT6 expression in endothelial cells. The overexpression of SIRT6 can mitigate minute CC-induced endothelial dysfunction. Expression of Nuclear factor erythroid2-related factor2 (Nrf2) is suppressed after minute CC treatment, whereas SIRT6 overexpression reverses this decrease in Nrf2 expression. Nrf2 activation also notably attenuates minute CC-induced endothelial dysfunction. SIRT6 depletion impairs vascular endothelial function and suppresses Nrf2 expression in hyperlipidemic mice | Homo sapiens |
malfunction | minute cholesterol crystals (CCs) significantly suppress SIRT6 expression in endothelial cells. The overexpression of SIRT6 can mitigate minute CC-induced endothelial dysfunction. Expression of Nuclear factor erythroid2-related factor2 (Nrf2) is suppressed after minute CC treatment, whereas SIRT6 overexpression reverses this decrease in Nrf2 expression. Nrf2 activation also notably attenuates minute CC-induced endothelial dysfunction. SIRT6 depletion impairs vascular endothelial function and suppresses Nrf2 expression in hyperlipidemic mice. Hearts, livers, spleens, lungs, kidneys and aortas from ecSIRT6-/- mice fed a normal diet do not show obvious pathological differences compared with ecSIRT6+/+ mice. Endothelium-specific SIRT6 knockout further impairs NO synthesis, significantly decreases eNOS activity and suppresses eNOS expression in hyperlipidemic mice. Endothelium-specific SIRT6 knockout further exacerbates endothelial dysfunction in hyperlipidemic mice | Mus musculus |
physiological function | sirtuin 6 (SIRT6), a nicotinamide adenine dinucleotide-dependent deacetylase, participates in various age-related disorders, such as dyslipidemia and cardiovascular diseases. SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation. Minute cholesterol crystals (CCs), which are generated after excess free cholesterol accumulation, form not only in mature atherosclerotic plaques but also extremely early in atherosclerosis. Endothelial dysfunction is an early feature of atherogenesis, role of SIRT6 in minute CC-induced endothelial dysfunction and the related mechanism, overview. SIRT6 rescues minute CC-induced endothelial dysfunction partly via Nrf2 activation | Mus musculus |
physiological function | sirtuin 6 (SIRT6), a nicotinamide adenine dinucleotide-dependent deacetylase, participates in various age-related disorders, such as dyslipidemia and cardiovascular diseases. SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation. Minute cholesterol crystals (CCs), which are generated after excess free cholesterol accumulation, form not only in mature atherosclerotic plaques but also extremely early in atherosclerosis. Endothelial dysfunction is an early feature of atherogenesis, role of SIRT6 in minute CC-induced endothelial dysfunction and the related mechanism, overview. SIRT6 rescues minute CC-induced endothelial dysfunction partly via Nrf2 activation. SIRT6 can protect HUVECs from minute CC-induced endothelial dysfunction | Homo sapiens |