Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.B41 extracted from

  • Jin, Z.; Xiao, Y.; Yao, F.; Wang, B.; Zheng, Z.; Gao, H.; Lv, X.; Chen, L.; He, Y.; Wang, W.; Lin, R.
    SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation (2020), Exp. Cell Res., 387, 111744 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene SIRT6, real-time PCR enzyme expression analysis Homo sapiens
gene SIRT6, real-time PCR enzyme expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of endothelium-specific SIRT6 knockout mice (Tie2-Cre/SIRT6flox/flox, defined as ecSIRT6-/-). Analysis of the effect of endothelium-specific SIRT6 depletion on hyperlipidemic mice Mus musculus
additional information generation of SIRT6-overexpressing human umbilical vein endothelial cells (HUVECS), significantly fewer THP-1 cells adher to SIRT6-overexpressing HUVECs exposed to minute CCs compared to control HUVECs Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-
nucleus
-
Mus musculus 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8N6T7
-
-
Mus musculus P59941 Apoe-/- mice, Tie2-Cre mice, and SIRT6-floxed (SIRT6flox/flox) mice
-

Source Tissue

Source Tissue Comment Organism Textmining
artery
-
Mus musculus
-
endothelial cell
-
Homo sapiens
-
endothelial cell
-
Mus musculus
-
endothelium
-
Homo sapiens
-
endothelium
-
Mus musculus
-
heart
-
Mus musculus
-
HUVEC cell
-
Homo sapiens
-
kidney
-
Mus musculus
-
liver
-
Mus musculus
-
lung
-
Mus musculus
-
spleen
-
Mus musculus
-
umbilical vein endothelial cell
-
Homo sapiens
-
vascular endothelial cell
-
Homo sapiens
-
vascular endothelial cell
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
nicotinamide adenine dinucleotide-dependent deacetylase
-
Homo sapiens
nicotinamide adenine dinucleotide-dependent deacetylase
-
Mus musculus
SIRT6
-
Homo sapiens
SIRT6
-
Mus musculus
sirtuin 6
-
Homo sapiens
sirtuin 6
-
Mus musculus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Homo sapiens
NAD+
-
Mus musculus

Expression

Organism Comment Expression
Homo sapiens minute cholesterol crystals significantly suppress SIRT6 expression in endothelial cells down
Mus musculus minute cholesterol crystals significantly suppress SIRT6 expression in endothelial cells down

General Information

General Information Comment Organism
malfunction minute cholesterol crystals (CCs) significantly suppress SIRT6 expression in endothelial cells. The overexpression of SIRT6 can mitigate minute CC-induced endothelial dysfunction. Expression of Nuclear factor erythroid2-related factor2 (Nrf2) is suppressed after minute CC treatment, whereas SIRT6 overexpression reverses this decrease in Nrf2 expression. Nrf2 activation also notably attenuates minute CC-induced endothelial dysfunction. SIRT6 depletion impairs vascular endothelial function and suppresses Nrf2 expression in hyperlipidemic mice Homo sapiens
malfunction minute cholesterol crystals (CCs) significantly suppress SIRT6 expression in endothelial cells. The overexpression of SIRT6 can mitigate minute CC-induced endothelial dysfunction. Expression of Nuclear factor erythroid2-related factor2 (Nrf2) is suppressed after minute CC treatment, whereas SIRT6 overexpression reverses this decrease in Nrf2 expression. Nrf2 activation also notably attenuates minute CC-induced endothelial dysfunction. SIRT6 depletion impairs vascular endothelial function and suppresses Nrf2 expression in hyperlipidemic mice. Hearts, livers, spleens, lungs, kidneys and aortas from ecSIRT6-/- mice fed a normal diet do not show obvious pathological differences compared with ecSIRT6+/+ mice. Endothelium-specific SIRT6 knockout further impairs NO synthesis, significantly decreases eNOS activity and suppresses eNOS expression in hyperlipidemic mice. Endothelium-specific SIRT6 knockout further exacerbates endothelial dysfunction in hyperlipidemic mice Mus musculus
physiological function sirtuin 6 (SIRT6), a nicotinamide adenine dinucleotide-dependent deacetylase, participates in various age-related disorders, such as dyslipidemia and cardiovascular diseases. SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation. Minute cholesterol crystals (CCs), which are generated after excess free cholesterol accumulation, form not only in mature atherosclerotic plaques but also extremely early in atherosclerosis. Endothelial dysfunction is an early feature of atherogenesis, role of SIRT6 in minute CC-induced endothelial dysfunction and the related mechanism, overview. SIRT6 rescues minute CC-induced endothelial dysfunction partly via Nrf2 activation Mus musculus
physiological function sirtuin 6 (SIRT6), a nicotinamide adenine dinucleotide-dependent deacetylase, participates in various age-related disorders, such as dyslipidemia and cardiovascular diseases. SIRT6 inhibits cholesterol crystal-induced vascular endothelial dysfunction via Nrf2 activation. Minute cholesterol crystals (CCs), which are generated after excess free cholesterol accumulation, form not only in mature atherosclerotic plaques but also extremely early in atherosclerosis. Endothelial dysfunction is an early feature of atherogenesis, role of SIRT6 in minute CC-induced endothelial dysfunction and the related mechanism, overview. SIRT6 rescues minute CC-induced endothelial dysfunction partly via Nrf2 activation. SIRT6 can protect HUVECs from minute CC-induced endothelial dysfunction Homo sapiens